O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of alpha-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous alpha-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.
Hilal Lashuel, Melek Firat Altay
Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri, Jiangtao Zhou
Hilal Lashuel, Anne-Laure Mahul Mellier