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The invention relates to methods for the preparation of method of preparation of Tau aggregates, including fibrils, fibrillar species, soluble and insoluble oligomeric species, new Tau aggregates and uses thereof. The invention further relates to the uses of the method of preparation of the so generated Tau aggregates for the identification and screening of modulators of Tau aggregation.
Henning Paul-Julius Stahlberg, Zhiva Skachokova