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Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.
Jérôme Waser, Durga Prasada Rao Hari, Romain Gaëtan Tessier, Abhaya Kumar Mishra
César Pulgarin, Michaël Bensimon, Stefanos Giannakis, Thomas Guillaume, Jérémie Decker