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Our group is working on the development of reliable access to biol. relevant, long, and modified RNA sequences. Here, we briefly present the chem. synthesis of such sequences with 2'-O-triisopropylsilyloxymethyl (= 2'-O-tom) protected ribonucleoside phosphoramidites, their template-directed enzymic ligation, and some examples of modified nucleotides, designed to promote structural and biol. studies. [on SciFinder (R)]
Vassily Hatzimanikatis, Jasmin Maria Hafner, Noushin Hadadi, Laurent Potvin-Trottier, Yuchen Gao
Nako Nakatsuka, Yang Yang, Bowen Zhu