Publication

Reduction of fibrous adhesion formation by a copolymer possessing an affinity for anionic surfaces

Résumé

Postsurgical adhesions represent a common complication following a variety of surgical procedures. We sought to develop and evaluate a water-soluble polymer that could self-assemble onto tissue surfaces, forming a barrier on the surface. A copolymer was synthesized so as to contain two components: one component adsorbed to the tissue surface, and the other created a steric barrier, thereby preventing cell interactions with the tissue surface, and perhaps altering the wound-healing response that leads to the formation of fibrous adhesions. The component selected for tissue binding was a water-soluble polycation, poly-L-lysine, which can bind to negative sites on glycoproteins, proteoglycans, and cells; and the component selected for steric stabilization was polyethylene glycol, a nonionic polymer that interacts poorly with proteins. Efficacy of lavage with an aqueous solution of the copolymer for the prevention of postsurgical abdominopelvic adhesions was assessed following a standard electrocautery injury of the uterine horns of rats. The copolymer resulted in an 88% reduction in the extent of adhesions that formed. In vitro studies designed to investigate the mechanism of this efficacy indicated that the copolymer may both hinder cell-tissue adhesive interactions and alter the process of fibrin formation. [on SciFinder (R)]

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Concepts associés (44)
Polymère
vignette|Fibres de polyester observées au Microscopie électronique à balayage. vignette|La fabrication d'une éolienne fait intervenir le moulage de composites résines/renforts. Les polymères (étymologie : du grec polus, plusieurs, et meros, partie) constituent une classe de matériaux. D'un point de vue chimique, un polymère est une substance composée de macromolécules et issue de molécules de faible masse moléculaire. Un polymère est caractérisé par le degré de polymérisation.
Acrylate polymer
An acrylate polymer (also known as acrylic or polyacrylate) is any of a group of polymers prepared from acrylate monomers. These plastics are noted for their transparency, resistance to breakage, and elasticity. Acrylate polymer is commonly used in cosmetics, such as nail polish, as an adhesive. The first synthesis of acrylic polymer was reported by G.W.A Kahlbaum in 1880. Acrylic elastomer is a general term for a type of synthetic rubber whose primary component is acrylic acid alkylester (ethyl or butyl ester).
Emulsion polymerization
Emulsion polymerization is a type of radical polymerization that usually starts with an emulsion incorporating water, monomer, and surfactant. The most common type of emulsion polymerization is an oil-in-water emulsion, in which droplets of monomer (the oil) are emulsified (with surfactants) in a continuous phase of water. Water-soluble polymers, such as certain polyvinyl alcohols or hydroxyethyl celluloses, can also be used to act as emulsifiers/stabilizers. The name "emulsion polymerization" is a misnomer that arises from a historical misconception.
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