Common Cold Unit

The Common Cold Unit (CCU) or Common Cold Research Unit (CCRU) was a unit of the British Medical Research Council which undertook laboratory and epidemiological research on the common cold between 1946 and 1989 and produced 1,006 papers. The Common cold Unit studied etiology, epidemiology, prevention, and treatment of common colds. It was set up on the site of the Harvard Hospital, a former military hospital at Harnham Down near Salisbury in Wiltshire. Common colds account for a third of all acute respiratory infections and the economic costs are substantial in terms of sick leave. Thirty volunteers were required every fortnight during trial periods. The unit advertised in newspapers and magazines for volunteers, who were paid a small amount. A stay at the unit was presented in these advertisements as an unusual holiday opportunity. The volunteers were infected with preparations of cold viruses and typically stayed for ten days. They were housed in small groups of two or three, with each group strictly isolated from the others during the course of the stay. Volunteers were allowed to go out for walks in the countryside south of Salisbury, but residential areas were out of bounds. Human coronaviruses, which are responsible for about 10% of common colds, were first isolated from volunteers at the unit in 1965. The CCU continually recruited volunteers for research into the common cold until its closure in 1990. The final director was David Tyrrell, whose autobiography describes his work at the CCU from 1957. The CCU was sometimes confused with the Microbiological Research Establishment at nearby Porton Down, a military unit with which it occasionally collaborated but was not officially connected. Our current understanding of colds began in 1914 when Dr. Kruse showed that nasal secretions from people with colds could be filtrated to make them free from bacteria and that inoculation of those filtrated washes into the nose of recipients caused the same illness. Christopher Andrewes and David Tyrrell refined these experiments at Harvard Hospital in Salisbury, England.