Paropamisadae or Parapamisadae (Greek: Παροπαμισάδαι) was a satrapy of the Alexandrian Empire in modern Afghanistan and Pakistan, which largely coincided with the Achaemenid province of Parupraesanna. It consisted of the districts of Sattagydia (Bannu basin), Gandhara (Kabul, Peshawar, and Taxila), and Oddiyana (Swat Valley). Paruparaesanna is mentioned in the Akkadian language and Elamite language versions of the Behistun Inscription of Darius the Great, whereas in the Old Persian version it is called Gandāra. The entire satrapy was subsequently ceded by Seleucus I Nicator to Chandragupta Maurya following a treaty.
Paropamisadae is the Latinized form of the Greek name Paropamisádai (Παροπαμισάδαι), which is in turn derived from Old Persian Para-uparisaina, meaning "Beyond the Hindu Kush", where the Hindu Kush is referred to as Uparisaina ("higher than the eagle").
In the Greek language and Latin, "Paropamisus" (Παροπαμισός, Paropamisós) came to mean the Hindu Kush.
In many Greek and Latin sources, particularly editions of Ptolemy's Geography where their realm is included on the 9th Map of Asia, the names of the people and region are given as Paropanisadae and Paropanisus. They also appeared less frequently as Parapamisadae and Parapamīsus (Παραπάμισος, Parapámisos), Paropamīsii, etc.
The name was also applied to a nearby river, probably the Obi river. The mountain range Selseleh-ye Safīd Kūh is also called Paropamisus or Paropamisus Mountains.
Strabo describes the region as follows:
The geographical position of the tribes is as follows: along the Indus are the Paropamisadae, above whom lies the Paropamisus mountain; then, towards the south, the Arachoti; then next, towards the south, the Gedroseni, with the other tribes that occupy the seaboard; and the Indus lies, latitudinally, alongside these places; and of these places, in part, some that lie along the Indus are held by Indians, although they formerly belonged to the Persians.