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Concept
Clustal
Summary
Clustal is a series of widely used computer programs used in bioinformatics for multiple sequence alignment. There have been many versions of Clustal over the development of the algorithm that are listed below. The analysis of each tool and its algorithm is also detailed in their respective categories. Available operating systems listed in the sidebar are a combination of the software availability and may not be supported for every current version of the Clustal tools. Clustal Omega has the widest variety of operating systems out of all the Clustal tools.
There have been many variations of the Clustal software, all of which are listed below:
Clustal: The original software for multiple sequence alignments, created by Des Higgins in 1988, was based on deriving phylogenetic trees from pairwise sequences of amino acids or nucleotides.
ClustalV: The second generation of the Clustal software was released in 1992 and was a rewrite of the original Clustal package. It introduced phylogenetic tree reconstruction on the final alignment, the ability to create alignments from existing alignments, and the option to create trees from alignments using a method called Neighbor joining.
ClustalW: The third generation, released in 1994, greatly improved upon the previous versions. It improved upon the progressive alignment algorithm in various ways, including allowing individual sequences to be weighted down or up according to similarity or divergence respectively in a partial alignment. It also included the ability to run the program in batch mode from the command line.
ClustalX: This version, released in 1997, was the first to have a graphical user interface.
ClustalΩ (Omega): The current standard version.
Clustal2: The updated versions of both ClustalW and ClustalX with higher accuracy and efficiency.
The papers describing the Clustal software have been very highly cited, with two of them amongst the most cited papers of all time.
The most recent version of the software is available for Windows, Mac OS, and Unix/Linux.
Official source
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