The estrous cycle (, originally ) is a set of recurring physiological changes induced by reproductive hormones in females of mammalian subclass Theria. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phases, otherwise known as "rest" phases, or by pregnancies. Typically, estrous cycles repeat until death. These cycles are widely variable in duration and frequency depending on the species. Some animals may display bloody vaginal discharge, often mistaken for menstruation. Many mammals used in commercial agriculture, such as cattle and sheep, may have their estrous cycles artificially controlled with hormonal medications for optimum productivity. The male equivalent, seen primarily in ruminants, is called rut. Mammals share the same reproductive system, including the regulatory hypothalamic system that produces gonadotropin-releasing hormone in pulses, the pituitary gland that secretes follicle-stimulating hormone and luteinizing hormone, and the ovary itself that releases sex hormones, including estrogens and progesterone. However, species vary significantly in the detailed functioning. One difference is that animals that have estrous cycles resorb the endometrium if conception does not occur during that cycle. Mammals that have menstrual cycles shed the endometrium through menstruation instead. Another difference is sexual activity. In species with estrous cycles , females are generally only sexually active during the estrus phase of their cycle. This is also referred to as being "in heat". In contrast, females of species with menstrual cycles can be sexually active at any time in their cycle, even when they are not about to ovulate. Humans have menstrual cycles rather than estrous cycles. They, unlike most other species, have concealed ovulation, a lack of obvious external signs to signal estral receptivity at ovulation (i.e., the ability to become pregnant). Animals with estrous cycles often have unmistakable outward displays of receptivity, ranging from engorged and colorful genitals to behavioral changes like mating calls.

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