The Tennessee River is the largest tributary of the Ohio River. It is approximately long and is located in the southeastern United States in the Tennessee Valley. The river was once popularly known as the Cherokee River, among other names, as the Cherokee people had their homelands along its banks, especially in what are now East Tennessee and northern Alabama. Additionally, its tributary, the Little Tennessee River, flows into it from Western North Carolina and northeastern Georgia, where the river also was bordered by numerous Cherokee towns. Its current name is derived from the Cherokee town, Tanasi, which was located on the Tennessee side of the Appalachian Mountains.
The Tennessee River is formed at the confluence of the Holston and French Broad rivers in present-day Knoxville, Tennessee. From Knoxville, it flows southwest through East Tennessee into Chattanooga before crossing into Alabama. It travels through the Huntsville and Decatur area before reaching the Muscle Shoals area, and eventually forms a small part of the state's border with Mississippi, before returning to Tennessee. The river misses Georgia by about 250 feet. The Tennessee river’s route northerly through Tennessee defines the boundary between two of Tennessee's Grand Divisions: Middle and West Tennessee.
The Tennessee–Tombigbee Waterway, a U.S. Army Corps of Engineers project providing navigation on the Tombigbee River and a link to the Port of Mobile, enters the Tennessee River near the Tennessee-Alabama-Mississippi boundary. This waterway reduces the navigation distance from Tennessee, north Alabama, and northern Mississippi to the Gulf of Mexico by hundreds of miles. The final part of the Tennessee's run is north through western Kentucky, where it separates the Jackson Purchase from the rest of the state. It flows into the Ohio River at Paducah, Kentucky.
The river has been dammed numerous times since the 1930s by Tennessee Valley Authority (TVA) projects.