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Languedoc-Roussillon wine, including the vin de pays labeled Vin de Pays d'Oc, is produced in southern France. While "Languedoc" can refer to a specific historic region of France and Northern Catalonia, usage since the 20th century (especially in the context of wine) has primarily referred to the northern part of the Languedoc-Roussillon region of France, an area which spans the Mediterranean coastline from the French border with Spain to the region of Provence. The area has around under vines and is the single biggest wine-producing region in the world, being responsible for more than a third of France's total wine production. In 2001, the region produced more wine than the United States. The history of Languedoc wines can be traced to the first vineyards planted along the coast near Narbonne by the early Greeks in the fifth century BC. Along with parts of Provence, these are the oldest planted vineyards in France. The region of Languedoc has belonged to France since the thirteenth century and the Roussillon was acquired from Spain in the mid-seventeenth century. The two regions were joined as one administrative region in the late 1980s. From the 4th century through the 18th and early 19th centuries, the Languedoc had a reputation for producing high quality wine. In Paris during the 14th century, wines from the St. Chinian area were prescribed in hospitals for their "healing powers". During the advent of the Industrial Age in the late 19th century, production shifted towards mass-produced le gros rouge—cheap red wine that could satisfy the growing work force. The use of highly prolific grape varieties produced high yields and thin wines, which were normally blended with red wine from Algeria to give them more body. The phylloxera epidemic in the 19th century severely affected the Languedoc wine industry, killing off many of the higher quality Vitis vinifera that were susceptible to the louse. American rootstock that was naturally resistant to phylloxera did not take well to the limestone soil on the hillside.