The Powhatan people (ˌpaʊhəˈtæn,_ˈhætən; also spelled Powatan) may refer to any of the Indigenous Algonquian people that are traditionally from eastern Virginia. All of the Powhatan groups descend from the Powhatan Confederacy. In some instances, The Powhatan may refer to one of the leaders of the people. This is most commonly the case in historical records from English colonial accounts. The Powhatans have also been known as Virginia Algonquians, as the Powhatan language is an eastern-Algonquian language, also known as Virginia Algonquian. It is estimated that there were about 14,000–21,000 Powhatan people in eastern Virginia when English colonists established Jamestown in 1607.
In the late 16th and early 17th centuries, a mamanatowick (paramount chief) named Wahunsenacawh created an organization by affiliating 30 tributary peoples, whose territory was much of eastern Virginia. They called this area Tsenacommacah ("densely inhabited Land"). Wahunsenacawh came to be known by English colonists as "The Powhatan (Chief)". Each of the tribes within this organization had its weroance (leader, commander), but all paid tribute to The Powhatan (Chief).
After Wahunsenacawh died in 1618, hostilities with colonists escalated under the chiefdom of his brother, Opchanacanough, who sought in vain to expel encroaching English colonists. His large-scale attacks in 1622 and 1644 met strong reprisals by the colonists, resulting in the near elimination of the tribe. By 1646, what is called the Powhatan Paramount Chiefdom by modern historians had been decimated. More important than the ongoing conflicts with the English colonial settlements was the high rate of deaths the Powhatans suffered due to new infectious diseases carried to North America by Europeans, such as measles and smallpox. The Native Americans did not have any immunity to these, which had been endemic to Europe and Asia for centuries. The wholesale deaths greatly weakened and hollowed out the Native American societies.
By the mid-17th century, the leaders of the colony were desperate for labor to develop the land.