Gundeshapur (𐭥𐭧𐭩𐭠𐭭𐭣𐭩𐭥𐭪𐭱𐭧𐭯𐭥𐭧𐭥𐭩, Weh-Andiōk-Šābuhr; New Persian: گندیشاپور, Gondēshāpūr) was the intellectual centre of the Sassanid Empire and the home of the Academy of Gundishapur, founded by Sassanid king Shapur I. Gundeshapur was home to a teaching hospital and had a library and a centre of higher learning. It has been identified with extensive ruins south of Shahabad, a village 14 km south-east of Dezful, to the road for Shushtar, in the present-day province of Khuzestan, southwest Iran.
It is not an organised archaeological place as of today, and except for ruins, it is full of remains like broken ceramics.
Despite the fame, recently some scholars have called Gundeshapur's overall historical importance, specifically, the existence of its hospital, into question.
The town fell into decline after the Muslim conquest of Persia, the city surrendering in 638. However, it continued to remain an important centre in the Muslim period. Ya'qub ibn al-Layth al-Saffar, the founder of the Saffarid dynasty, made Gundeshapur his residence three years before his sudden death in 879. His tomb became one of the most prominent sites in the city.
The Middle Persian word Gondēšāpūr (or Gundēšāpūr) is a corrupted form. It may be from wandēw Šāpūr, means "acquired by Shapur", or from Gund-dēz-i Shāpūr, means "military fortress of Shapur", or from Weh-Andiyok-Shāpūr, "Better-than-Antioch of Shapur".
In Classical Syriac, the town was called ܒܝܬ ܠܦܛ Bēth Lapaṭ,; in Greek Bendosabora; in جنديسابور Jundaysābūr; and in New گندیشاپور.
After his conquest of the Roman city of Antioch in 256, the Sasanian King of Kings (shahanshah) Shapur I founded the city of Gundeshapur, situated between Susa and Shushtar. The city, constructed as a place to settle Roman prisoners of war, subsequently became a Sasanian royal winter residence and the capital of the Khuzistan province. Gundeshapur was one of the four main cities of the province, along with Susa, Karka d-Ledan, and Shushtar. Gundeshapur was mainly inhabited by Christians, and served as the East-Syrian metropolitan see of Bet Huzaye.