Category
Anesthesia
Related publications (60)
Raspberry-Pi based system for propofol monitoring
Sandro Carrara, Francesca Stradolini, Danilo Demarchi, Tugba Kilic, Abuduwaili Tuoheti
Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...
ELSEVIER SCIENCE BV2018Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum
Giovanni De Micheli, Giovanni Boero, Francesca Stradolini, Irene Taurino, Tugba Kilic
In this work, we present a novel electrochemical cleaning procedure for long-term electrochemical monitoring of propofol by using boron-doped diamond (BDD) and pencil graphite electrode (PGE). Propofol is an anesthetic that is widely used for long-lasting ...
2018Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Michael van der Kooij, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...
Nature Publishing Group2018Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum
Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Irene Taurino, Ioulia Tzouvadaki, Nima Aliakbarinodehi, Sattar Akbari Nakhjavani
Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...
2018Graphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties
Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki, Nima Aliakbarinodehi
Improved sensitivity and continuous monitoring of therapeutic compounds are two of the most highlighted concerns for the treatment of malignant diseases, such as cancer. We demonstrated ultrasensitive screening of etoposide, a therapeutic compound widely-u ...
2018Dynamic reorganization of intrinsic functional networks in the mouse brain
Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Maria Giulia Preti, Joanes Grandjean, Markus Rudin
Functional connectivity (FC) derived from resting-state functional magnetic resonance imaging (rs-fMRI) allows for the integrative study of neuronal processes at a macroscopic level. The majority of studies to date have assumed stationary interactions betw ...
Elsevier2017Energy metabolism in the rat cortex under thiopental anaesthesia measured
Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay
Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...
Wiley-Blackwell2017Designing Safer Analgesics via mu-Opioid Receptor Pathways
Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especial ...
Elsevier Science London2017Computational design of environmental sensors for the potent opioid fentanyl
We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to opt ...
Elife Sciences Publications Ltd2017Towards 3D facial morphometry
In anesthesiology, the detection and anticipation of difficult tracheal intubation is crucial for patient safety. When undergoing general anesthesia, a patient who is unexpectedly difficult to intubate risks potential life-threatening complications with po ...
EPFL2017