Creationism

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De l'acoustique des églises en Suisse

Victor Desarnaulds

The existence of the fundamental conflict in churches between the desirable acoustic conditions for music and for speech intelligibility prompted this dissertation. It tackles the subject not only under the acoustical perspective but also in the historical ...

EPFL2002

Changing the substrate specificity of cytochrome c peroxidase using directed evolution

Kai Johnsson, Petra Tafelmeyer

Cytochrome c peroxidase (I) from Saccharomyces cerevisiae was subjected to directed mol. evolution to generate mutants with increased activity against ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)]. Using a combination of DNA shuffling and s ...

2001

Evolutionary approaches to study cytochrome c peroxidase

Kai Johnsson, Petra Tafelmeyer

A review with 15 refs. Directed mol. evolution of enzymes and proteins has emerged as an extremely powerful method to create proteins with novel properties, both for practical applications as well as for mechanistic studies. To demonstrate the underlying p ...

2001

Model of geometrical and smooth muscle tone adaptation of carotid artery subject to step change in pressure

Nikolaos Stergiopoulos, Jean-Jacques Meister

Recent experimental studies have shown significant alterations of the vascular smooth muscle (VSM) tone when an artery is subjected to an elevation in pressure. Therefore, the VSM participates in the adaptation process not only by means of its synthetic ac ...

2001

Holographic multiplexing in photorefractive polymers

Demetri Psaltis

A new multiplexing schedule is derived for multiplexing holograms in photorefractive polymers which do not exhibit mono-exponential recording behavior. An M-number (M/#) of 0.3 was measured experimentally by recording 20 holograms of roughly equal strength ...

2000

Directed molecular evolution of cytochrome c peroxidase

Kai Johnsson, Petra Tafelmeyer

Cytochrome c peroxidase (CCP) from Saccharomyces cerevisiae was subjected to directed mol. evolution to generate mutants with increased activity against the classical peroxidase substrate, guaiacol, thus changing the substrate specificity of CCP from the p ...

2000

In-situ OH kinetics study providing an indicator for ozone formation limitation

Hubert van den Bergh, Bertrand Calpini, Alain Clappier

Hydroxyl radicals dominate daytime tropospheric chem., responsible for reactive removal of most trace gases (e.g., volatile org. compds.[VOC]), and is an active participant in the NO and NO2 cycle. Pump-and-probe LIDAR was used to examine the OH- chem. in ...

1999

Learning and Evolution

Dario Floreano

In the last few years several researchers have resorted to artificial evolution (e.g. genetic algorithms) and learning techniques (e.g. neural networks) for studying the interaction between learning and evolution. These studies have been conducted for two ...

1999

Retrospective: Tempest and Typhoon: User-level Shared Memory

James Richard Larus, David Wood

Tempest and Typhoon have emerged as among the most influential contributions of the Wisconsin Wind Tunnel project, a collaborative effort with Prof. Mark D. Hill, several staff members, and a large group of graduate students. This retrospective focuses on ...

ACM1998

The evolution of 'bricolage'

Denis Duboule

The past ten years of developmental genetics have revealed that most of our genes are shared by other species throughout the animal kingdom. Consequently, animal diversity might largely rely on the differential use of the same components, either at the ind ...

1998