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The presence of expanded poly-glutamine (polyQ) repeats in proteins is directly linked to the pathogenesis of several neurodegenerative diseases, including Huntington's disease. However, the molecular and structural basis underlying the increased toxicity ...
The preparation of the polyketide natural products anguinomycin C and D is reported based on key steps such as Negishi stereoinversion cross coupling, Jacobsen Cr(III)-catalyzed Hetero Diels−Alder reaction, Evans B-mediated syn-aldol chemistry, and B-alkyl ...
The Swiss architectural photographer Heinrich Helfenstein (1946–2020) trained as a linguist, his approach shaped by semiology and post-structuralism. Having worked as Aldo Rossi’s assistant at ETH in the 1970s, his early photographs illustrated the latter’ ...
The paper discussed different types of reactions to the emergence of Yuri Lotman's structuralism in the Soviet Union after 1960 ...
2023
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ABCG2 is an ATP-binding cassette (ABC) transporter whose function affects the pharmacokinetics of drugs and contributes to multidrug resistance of cancer cells. While its interaction with the endogenous substrate estrone-3-sulfate (E1S) has been elucidated ...
Structural relations established among agents influence the performance of decentralized service discovery process in multiagent systems. Moreover, distributed systems should be able to adapt their structural relations to changes in environmental condition ...
