Publications related to Neurodegenerative disease

Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate

Paolo De Los Rios, Pierre Goloubinoff

During mild heat-stress, a native thermolabile polypeptide may partially unfold and transiently expose water-avoiding hydrophobic segments that readily tend to associate into a stable misfolded species, rich in intra-molecular non-native beta-sheet structu ...

2011

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Horst Vogel, Yury Tsybin, Diego Chiappe, Marc Moniatte, Adrian Schmid, Enrico Condemi

Tissue transglutaminase (TGase) has been implicated in a number of cellular processes and disease states, where the enzymatic actions of TGase may serve in both, cell survival and apoptosis. To date, the precise functional properties of TGase in cell survi ...

American Society for Biochemistry and Molecular Biology2011

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Philippe Renaud, Robert Meissner, Anja Kunze, Serena Brando

This communication presents a novel experi- mental model for Alzheimer studies, where connected pri- mary neurons were set into subtend, co-pathological states. Cortical neurons were cultured in two separated cell com- partments in a microfluidic device. A ...

Wiley-Blackwell2011

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Bruno Lemaitre, Patrick Fraering, Mitko Dimitrov, Takayuki Kuraishi, Isabelle Chang

Prenatal exposure to mercury causes neurodevelopmental disorders and neurological pathologies in infants, such as microcephaly and mental retardation. Despite critical importance, the molecular interactions leading to mercury toxicity are yet to be elucida ...

2011

Study of the dynamics of protein aggregation with a Bloch Surface Wave sensor

Hans Peter Herzig, Vincent Paeder, Valeria Musi

We present a study of the dynamics of protein aggregation using an interferometric Bloch surface wave sensing scheme. We demonstrate the ability to detect, during thermal incubation, the aggregation of proteins related to conformational diseases. ...

2011

Genetic Mouse Models of Neurodegenerative Diseases

Darren Moore, Alzbeta Trancikova, David Ramonet Jimenez

Neurodegenerative diseases are generally characterized by the selective degeneration of particular neuronal populations and the accumulation of abnormal or aggregated proteins within, but occasionally external to, neurons in affected brain regions. These d ...

2011

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

Ursula Röthlisberger, Geoffrey Wood

The distinct conformational dependence of chemical shifts caused by R-helices and β-sheets renders NMR chemical shift analysis a powerful tool for the structural determination of proteins. However, the time scale of NMR experiments can make a secondary str ...

2011

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Philippe Guillaume Coune

Although the overabundance of human alpha-synuclein in nigral dopaminergic neurons is considered to play a pathogenic role in Parkinson's disease (PD), it remains unclear how alpha-synuclein leads to neuronal degeneration and motor symptoms. Here, we explo ...

Ios Press2011

Detection of protein aggregation with a Bloch surface wave based sensor

Hans Peter Herzig, Vincent Paeder, Lubos Hvozdara, Valeria Musi, Sylvain Herminjard

We present the innovative application of a Bloch surface wave based sensor to the detection of protein aggregation. In Hen Egg White Lysozyme (HEWL) solutions, aggregates are discriminated from the monomeric forms in a label-free detection scheme. ...

Elsevier2011

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Neurodegenerative disease

Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Study of the dynamics of protein aggregation with a Bloch Surface Wave sensor

Genetic Mouse Models of Neurodegenerative Diseases

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Detection of protein aggregation with a Bloch surface wave based sensor

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Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Detection of protein aggregation with a Bloch surface wave based sensor

Probing the different chaperone activities of the bacterial HSP70-HSP40 system using a thermolabile luciferase substrate

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Study of the dynamics of protein aggregation with a Bloch Surface Wave sensor

Genetic Mouse Models of Neurodegenerative Diseases

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation