Marilyne AndersenMarilyne Andersen is a Full Professor of Sustainable Construction Technologies and heads the Laboratory of Integrated Performance in Design (LIPID) that she launched in the Fall of 2010. She was Dean of the School of Architecture, Civil and Environmental Engineering (ENAC) at EPFL from 2013 to 2018 and is the Academic Director of the Smart Living Lab in Fribourg. She also co-leads the Student Kreativity and Innovation Laboratory (SKIL) at ENAC. Before joining EPFL as a faculty, she was an Assistant Professor then Associate Professor tenure-track in the Building Technology Group of the MIT School of Architecture and Planning and the Head of the MIT Daylighting Lab that she founded in 2004. She has also been Invited Professor at the Singapore University of Technology and Design in 2019. Marilyne Andersen owns a Master of Science in Physics and specialized in daylighting through her PhD in Building Physics at EPFL in the Solar Energy and Building Physics Laboratory (LESO) and as a Visiting Scholar in the Building Technologies Department of the Lawrence Berkeley National Laboratory in California. Her research lies at the interface between science, engineering and architectural design with a dedicated emphasis on the impact of daylight on building occupants. Focused on questions of comfort, perception and health and their implications on energy considerations, these research efforts aim towards a deeper integration of the design process with daylighting performance and indoor comfort, by reaching out to various fields of science, from chronobiology and neuroscience to psychophysics and computer graphics. She is leveraging this research in practice through OCULIGHT dynamics, a startup company she co-founded, which offers specialized consulting services on daylight performance and its psycho-physiological effects on building occupants. She is the author of more than 200 papers published in peer-reviewed journals and international conferences and the recipient of several grants and awards including: the Daylight Award for Research (2016), eleven publication awards and distinctions (2009, 2011, 2012, 2015, 2018, 2019) including the Taylor Technical Talent Award 2009 granted by the Illuminating Engineering Society, the 3M Non-Tenured Faculty Grant (2009), the Mitsui Career Development Professorship at MIT (2008) and the EPFL prize of the Chorafas Foundation awarded to her PhD thesis in Sustainability (2005). Her research or teaching has been supported by professional, institutional and industrial organizations such as: the Swiss and the U.S. National Science Foundations, the Velux Foundation, the European Horizon 2020 program, the Boston Society of Architects, the MIT Energy Initiative and InnoSuisse. She was the leader and faculty advisor of the Swiss Team and its NeighborHub project, who won the U.S. Solar Decathlon 2017 competition with 8 podiums out of 10 contests. She is a member of the Board of the LafargeHolcim Foundation for Sustainable Construction and Head of its Academic Committee. She is also a member of the Editorial Board of the journal Building and Environment by Elsevier, and of the journals LEUKOS (of the Illuminating Engineering Society) and Buildings and Cities, by Taylor and Francis. She is expert to the Innovation Council of InnoSuisse and Founding member as well as Board member of the Foundation Culture du Bâti (CUB), and is also founding member of the Daylight Academy and an active member of several committees of the Illuminating Engineering Society (IES) and International Commission on Illumination (CIE).
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
François MaréchalPh D. in engineering Chemical process engineer
Researcher and lecturer in the field of computer aided process and energy systems engineering.
Lecturer in the mechanical engineering, electrical engineering and environmental sciences engineering in EPFL.
I'm responsible for the Minor in Energy of EPFL and I'm involved in 3 projects of the Competence Center in Energy and Mobility (2nd generation biofuel, Wood SOFC, and gas turbine development with CO2 mitigation) in which i'm contributing to the energy conversion system design and optimisation.
Short summary of my scientific carrer
After a graduation in chemical engineering from the University of Liège, I have obtained a Ph. D. from the University of Liège in the LASSC laboratory of Prof. Kalitventzeff (former president of the European working party on computer aided process engineering). This laboratory was one of the pioneering laboratory in the field of Computer Aided Process Engineering.
In the group of Professor Kalitventzeff, I have worked on the development and the applications of data reconciliation, process modelling and optimisation techniques in the chemical process industry, my experience ranges from nuclear power stations to chemical plants. In the LASSC, I have been responsible from the developments in the field of rational use of energy in the industry. My first research topic has been the methodological development of process integration techniques, combining the use of pinch based methods and of mathematical programming: e.g. for the design of multiperiod heat exchanger networks or Mixed integer non linear programming techniques for the optimal management of utility systems. Fronted with applications in the industry, my work then mainly concentrated on the optimal integration of utility systems considering not only the energy requirements but the cost of the energy requirements and the energy conversion systems. I developed methods for analysing and integrating the utility system, the steam networks, combustion (including waste fuel), gas turbines or other advanced energy conversion systems (cogeneration, refrigeration and heat). The techniques applied uses operation research tools like mixed integer linear programming and exergy analysis. In order to evaluate the results of the utility integration, a new graphical method for representing the integration of the utility systems has been developed. By the use of MILP techniques, the method developed for the utility integration has been extended to handled site scale problems, to incorporate environmental constraints and reduce the water usage. This method (the Effect Modelling and Optimisation method) has been successfully applied to the chemical plants industry, the pulp and paper industry and the power plant. Instead of focusing on academic problems, I mainly developed my research based on industrial applications that lead to valuable and applicable patented results. Recently the methods developed have been extended to realise the thermoeconomic optimisation of integrated systems like fuel cells. My present R&D work concerns the application of multi-objective optimisation strategies in the design of processes and integrated energy conversion systems.
Since 2001, Im working in the Industrial Energy Systems Laboratory (LENI) of Ecole Polytechnique fédérale de Lausanne (EPFL) where Im leading the R&D activities in the field of Computer Aided Analysis and Design of Industrial Energy Systems with a major focus on sustainable energy conversion system development using thermo-economic optimisation methodologies. A part from the application and the development of process integration techniques, that remains my major field of expertise, the applications concern :
Rational use of water and energy in Industrial processes and industrial production sites : projects with NESTLE, EDF, VEOLIA and Borregaard (pulp and paper).Energy conversion and process design : biofuels from waste biomass (with GASNAT, EGO and PSI), water dessalination and waste water treatment plant (VEOLIA), power plant design (ALSTOM), Energy conversion from geothermal sources (BFE). Integrated energy systems in urban areas : together with SCANE and SIG (GE) and IEA annexe 42 for micro-cogeneration systems.
I as well contributed to the definition of the 2000 Watt society and to studies concerning the emergence of green technologies on the market in the frame of the Alliance for Global Sustainability.
Vincent Pierre LamirandAfter a PhD on the measurement of (p,n) reactions cross sections on small accelerators (IRSN, France), I have worked on the development of neutron detectors and measurement methods for reactor physics (CEA, France). I am part of the LRS staff since October 2014.
André SchiperAndré Schiper graduated in Physics from the ETHZ in Zurich in 1973 and received the PhD degree in Computer Science from EPFL in 1980. He has been a professor of computer science at EPFL since 1985, leading the Distributed Systems Laboratory. During the academic year 1992-1993 he was on sabbatical leave at the University of Cornell, Ithaca, New York (working with Ken Birman and Aleta Ricciardi), and in 2004-2005 at the Ecole Polytechnique in Palaiseau, France (working with Bernadette Charron-Bost). His research interests are in the area of dependable distributed systems, middleware support for dependable systems, replication techniques (including for database systems), group communication, distributed transactions, and MANETs (mobile ad-hoc networks).
Prof. Schiper is member of the editorial boards of
Distributed Computing (DC), Springer Verlag - ACM,
Transactions on Dependable and Secure Computing (TDSC), IEEE,
International Journal of Security and Networks (Inderscience).
Pierre DillenbourgA former teacher in elementary school, Pierre Dillenbourg graduated in educational science (University of Mons, Belgium). He started his research on learning technologies in 1984. In 1986, he has been on of the first in the world to apply machine learning to develop a self-improving teaching system. He obtained a PhD in computer science from the University of Lancaster (UK), in the domain of artificial intelligence applications for education. He has been assistant professor at the University of Geneva. He joined EPFL in 2002. He has been the director of Center for Research and Support on Learning and its Technologies, then academic director of Center for Digital Education, which implements the MOOC strategy of EPFL (over 2 million registrations). He is full professor in learning technologies in the School of Computer & Communication Sciences, where he is the head of the CHILI Lab: "Computer-Human Interaction for Learning & Instruction ». He is the director of the leading house DUAL-T, which develops technologies for dual vocational education systems (carpenters, florists,...). With EPFL colleagues, he launched in 2017 the Swiss EdTech Collider, an incubator with 80 start-ups in learning technologies. He (co-)-founded 4 start-ups, does consulting missions in the corporate world and joined the board of several companies or institutions. In 2018, he co-founded LEARN, the EPFL Center of Learning Sciences that brings together the local initiatives in educational innovation. He is a fellow of the International Society for Learning Sciences. He currently is the Associate Vice-President for Education at EPFL.
