Fabrizio CarboneBirth 20/04/1976
Master degree: University of Pavia "optoelectronic engineering". September 2001.
Reasearch scientist at Pirelli Labs, Milan Italy between September 2000 and August 2002.
PhD in condensed matter physics from the University of Geneva, prof. van der Marel gorup. January 2007
Post doc in physical chemistry at Caltech in prof. Zewail`s group. March 2007-April 2009
Jean-Philippe BrantutI did my PhD at the Institut d'Optique under the direction of Philippe Bouyer and Alain Aspect, before moving to ETHZ in the group of Tilman Esslinger, first as a post-doc then as a senior scientist. There I developed in particular the method allowing for a quantum simulation of nano-electronic devices with ultracold quantum gases.Since september 2016, I hold the Fondation Sandoz chair in physics of quantum gases at EPFL. There, my group has developed the first cold atoms machine combining Fermi gases with cavity-quantum electrodynamics. We use it to explore new ways of measuring and manipulating quantum matter.
Christian GruberOriginaire de Neuchâtel, Christian Gruber est né à Orbe (VD) le 20 juillet 1939. Il étudie la physique à l'Université de Lausanne où il obtient son diplôme en 1963. Il poursuit ses études à l'Université de Princeton, aux Etats-Unis, tout en fonctionnant comme assistant: il y fait un Master en 1965 puis un doctorat, Ph. D. en physique théorique avec le prof. A. S. Wightmann en 1968.
Il est ensuite boursier à l'Institut des Hautes Etudes Scientifiques à Bures-sur-Yvette (France). Premier assistant au Laboratoire de physique théorique à l'EPFL, de 1971 à 1974, il est nommé professeur titulaire en 1975, puis extraordinaire neuf ans plus tard et enfin, professeur ordinaire en 1987. Chef du département de 1988 à 1990, il prend, depuis 1990, la direction de l'Institut de physique théorique.
Son enseignement porte sur la mécanique, la thermodynamique, la physique statistique, la physique quantique, et la relativité générale. Il poursuit des recherches dans le domaine des résultats rigoureux en mécanique statistique : propriétés des états d'équilibre, systèmes sur réseaux, systèmes coulombiens; études sur les transitions de phase, diagrammes de phase et tension superficielle. Il a dirigé plusieurs thèses sur la mécanique statistique classique et quantique de l'équilibre.
Diplômes:
Diploma in Physics-1963-Univ. de Lausanne, CH
M.S.-1965-Princeton Univ., US
Ph.D.-1968-Princeton Univ., US
Luc ThévenazLuc Thévenaz received in 1982 the M.Sc. degree in astrophysics from the Observatory of Geneva, Switzerland, and in 1988 the Ph.D. degree in physics from the University of Geneva, Switzerland. He developed at this moment his field of expertise, i.e. fibre optics. In 1988 he joined the Swiss Federal Institute of Technology of Lausanne (EPFL) where he currently leads a research group involved in photonics, namely fibre optics and optical sensing. Research topics include Brillouin-scattering fibre sensors, nonlinear fibre optics, slow & fast light and laser spectroscopy in gases. His main achievements are: - the invention of a novel configuration for distributed Brillouin fibre sensing based on a single laser source, resulting in a high intrinsic stability making for the first time field measurements possible, - the development of a photoacoustic gas trace sensor using a near infra-red semiconductor laser, detecting a gas concentration at the ppb level, - the first experimental demonstration of optically-controlled slow & fast light in optical fibres, realized at ambient temperature and operating at any wavelength since based on stimulated Brillouin scattering. The first negative group velocity of light was also realized in optical fibres using this approach. In 1991, he visited the PUC University in Rio de Janeiro, Brazil where he worked on the generation of picosecond pulses in semiconductor lasers. In 1991-1992 he stayed at Stanford University, USA, where he participated in the development of a Brillouin laser gyroscope. He joined in 1998 the company Orbisphere Laboratories SA in Neuchâtel, Switzerland, as Expert Scientist to develop gas trace sensors based on photoacoustic laser spectroscopy. In 1998 and 1999 he visited the Korea Advanced Institute of Science and Technology (KAIST) in Daejon, South Korea, where he worked on fibre laser current sensors. In 2000 he co-founded the spin-off company Omnisens that is developing and commercializing advanced photonic instrumentation. In 2007 he visited Tel Aviv University where he studied the all-optical control of polarization in optical fibres. During winter 2010 he stayed at the University of Sydney where he studied applications of stimulated Brillouin scattering in chalcogenide waveguides. In 2014 he stayed at the Polytechnic University of Valencia where he worked on microwave applications of stimulated Brillouin scattering. He was member of the Consortium in the FP7 European Project GOSPEL "Governing the speed of light", was Chairman of the European COST Action 299 "FIDES: Optical Fibres for New Challenges Facing the Information Society" and is author or co-author of some 480 publications and 12 patents. He is now Coordinator of the H2020 Marie Skłodowska-Curie Innovative Training Networks FINESSE (FIbre NErve Systems for Sensing). He is co-Executive Editor-in-Chief of the journal "Nature Light: Science & Applications" and is Member of the Editorial Board (Associate Editor) for the journal "APL Photonics" & "Laser & Photonics Reviews". He is also Fellow of both the IEEE and the Optical Society (OSA).
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
