François AvellanProf. François Avellan, director of the EPFL Laboratory for Hydraulic Machines, graduated in Hydraulic Engineering from Ecole nationale supérieure d'hydraulique, Institut national polytechnique de Grenoble, France, in 1977 and, in 1980, got his doctoral degree in engineering from University of Aix-Marseille II, France. Research associate at EPFL in 1980, he is director of the EPFL Laboratory for Hydraulic Machines since 1994 and, in 2003, was appointed Ordinary Professor in Hydraulic Machinery. Supervising 37 EPFL doctoral theses, he was distinguished by SHF, Société hydrotechnique de France, awarding him the "Grand Prix 2010 de l'hydrotechnique". His main research domains of interests are hydrodynamics of turbine, pump and pump-turbines including cavitation, hydro-acoustics, design, performance and operation assessments of hydraulic machines. Prof. Avellan was Chairman of the IAHR Section on Hydraulic Machinery and Systems from 2002 to 2012. He has conducted successfully several Swiss and international collaborative research projects, involving key hydropower operators and suppliers, such as:
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Coordination for the FP7 European project n° 608532 "HYPERBOLE: HYdropower plants PERformance and flexiBle Operation towards Lean integration of new renewable Energies" (2013-2017);
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Deputy Head of the Swiss Competence Center for Energy Research – Supply of Electricity (SCCER-SoE) to carry out innovative and sustainable research in the areas of geo-energy and hydropower for phase I (2013-2016) and Phase II (2017, 2010) to be approved.
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EUREKA European research projects: N° 4150 and N° 3246, "HYDRODYNA, Harnessing the dynamic behavior of pump-turbines", (2003-2011), N° 1605, "FLINDT, Flow Investigation in Draft Tubes", http://flindt.epfl.ch/, (1997-2002). N° 2418, "SCAPIN, Stability of Operation of Francis turbines, prediction and modeling";
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Swiss KTI/CTI research projects with GE Renewable Energy (anc. ALSTOM Hydro), Birr, ANDRITZ Hydro, Kriens, FMV, Sion, Groupe E, Granges-Paccot, Power Vision engineering, Ecublens and SULZER Pumps, Winterthur.
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ETH Domain, HYDRONET Project for the Competence Center Energy and Mobility, PSI Villingen.
Furthermore, he is involved in scientific expertise and independent contractual experimental validations of turbines and pump turbines performances for the main hydropower plants in the world. In recognition for his work as Convenor of the TC4 working group of experts in editing the IEC 60193 standard he received the "IEC 1906 Award" from the International Electrotechnical Commission. Michel BierlaireBorn in 1967, Michel Bierlaire holds a PhD in Mathematical Sciences from the Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium (University of Namur). Between 1995 and 1998, he was research associate and project manager at the Intelligent Transportation Systems Program of the Massachusetts Institute of Technology (Cambridge, Ma, USA). Between 1998 and 2006, he was a junior faculty in the Operations Research group ROSO within the Institute of Mathematics at EPFL. In 2006, he was appointed associate professor in the School of Architecture, Civil and Environmental Engineering at EPFL, where he became the director of the Transport and Mobility laboratory. Since 2009, he is the director of TraCE, the Transportation Center. From 2009 to 2017, he was the director of Doctoral Program in Civil and Environmental Engineering at EPFL. In 2012, he was appointed full professor at EPFL. Since September 2017, he is the head of the Civil Engineering Institute at EPFL. His main expertise is in the design, development and applications of models and algorithms for the design, analysis and management of transportation systems. Namely, he has been active in demand modeling (discrete choice models, estimation of origin-destination matrices), operations research (scheduling, assignment, etc.) and Dynamic Traffic Management Systems. As of August 2021, he has published 136 papers in international journals, 4 books, 41 book chapters, 193 articles in conference proceedings, 182 technical reports, and has given 195 scientific seminars. His Google Scholar h-index is 68. He is the founder, organizer and lecturer of the EPFL Advanced Continuing Education Course "Discrete Choice Analysis: Predicting Demand and Market Shares". He is the founder of hEART: the European Association for Research in Transportation. He was the founding Editor-in-Chief of the EURO Journal on Transportation and Logistics, from 2011 to 2019. He is an Associate Editor of Operations Research. He is the editor of two special issues for the journal Transportation Research Part C. He has been member of the Editorial Advisory Board (EAB) of Transportation Research Part B since 1995, of Transportation Research Part C since January 1, 2006.
Olivier SchneiderAfter his thesis defense in particle physics in 1989 at University of Lausanne, Olivier Schneider joins LBL, the Lawrence Berkeley Laboratory (California), to work on the CDF experiment at the Tevatron in Fermilab (Illinois), first as a research fellow supported by the Swiss National Science Foundation, and later as a post-doc at LBL. He participates in the construction and commissioning of the first silicon vertex detector to operate successfully at a hadron collider; this detector enabled the discovery of the sixth quark, named "top". Since 1994, he comes back to Europe and participates in the ALEPH experiment at CERN's Large Electron-Positron Collider, as CERN fellow and then as CERN scientific staff. He specializes in heavy flavour physics. In 1998, he becomes associate professor at University of Lausanne, then extraordinary professor at the Swiss Institute of Technology Lausanne (EPFL) in 2003, and finally full professor at EPFL in 2010. Having worked since 1997 on the preparation of the LHCb experiment at CERN's Large Hadron Collider, which started operation in 2009, he is now analyzing the first data. He also contributes since 2001 to the exploitation of the data recorded at the Belle experiment (KEK laboratory, Tsukuba, Japan). These two experiments study mainly the decays of hadrons containing a b quark, as well CP violation, i.e. the non-invariance under the symmetry between matter and antimatter.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Vassily HatzimanikatisDr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Vassily received a PhD and an MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology in Zurich (ETHZ), Switzerland. Prior to joining EPFL, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, and he has been assistant professor at Northwestern University, at Illinois, USA.
Vassilys research interests are in the areas of computational systems biology, biotechnology, and complexity. He is associate editor of the journals Biotechnology & Bioengineering, Metabolic Engineering and Integrative Biology, and he serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering, Journal of Chemical Technology and Biotechnology, and Industrial Biotechnology. He has written over 70 technical publications and he is co-inventor in three patents and patent applications.
Vassily is a fellow of the American Institute for Medical and Biological Engineering (2010), he was a DuPont Young Professor (2001-2004), and he has also received the Jay Bailey Young Investigator Award in Metabolic Engineering (2000), and the ACS Elmar Gaden Award (2011).
Mark PaulyMark Pauly is a full professor at the School of Computer and Communication Sciences at EPFL. Prior to joining EPFL, he was assistant professor at the CS department of ETH Zurich since April 2005. From August 2003 to March 2005 he was a postdoctoral scholar at Stanford University, where he also held a position as visiting assistant professor during the summer of 2005. He received his Ph.D. degree (with distinction) in 2003 from ETH Zurich and his M.S. degree (with highest honors) in 1999 from TU Kaiserslautern. His research interests include computer graphics and animation, shape modeling and analysis, geometry processing, architectural geometry, and digital fabrication. He received the ETH medal for outstanding dissertation, was awarded the Eurographics Young Researcher Award in 2006 and the Eurographics Outstanding Technical Contributions Award in 2016.
Aurelio BayAurelio Bay graduated in physics at the University of Lausanne (UNIL) in 1980 and got his PhD degree from the same institution in 1986 for a work on the determination of the axial form factor of the ? meson.
He then went to Lawrence Berkeley Laboratories (LBL), USA as a post doc for two years, where he worked on the TPC/2? Electromagnetic Calorimeter and the SSC/LHC detector. He then came back to Europe and was named Maître Assistant at University of Geneva till 1994, where he started working at the L3 experiment of LEP at CERN.
He was appointed Assistant Professor at the University of Lausanne in 1994 and Full Professor in 1998, continuing working at LEP, LEP2 and LHCb at CERN , and starting a collaboration at BELLE experiment at KEK, Tsukuba (Japan).
At the University of Lausanne he was Director of the Institute of High Energy Physics, Deputy Director of the Physics Department and Deputy of the Dean of the Faculty of Sciences.
In 2003, following the merge of UNIL physics department into the EPFL School of Basic Sciences, he was appointed Full Professor at Ecole Polytechnique Fédérale de Lausanne (EPFL), and Director of the EPFL Laboratory of High Energy Physics.
Mohamed FarhatM. Farhat was born in Casablanca in 1962 (Moroccan citizen). He graduated at Ecole Nationale Supérieure d'Hydraulique et de Mécanique de Grenoble (France. He joined The LMH laboratory in 1986 as research assistant. He completed in 1994 a Ph.D. thesis on Cavitation. He joined the R&D department of Hydro-Quebec in Montréal (Canada) in 1995 where he was in charge of several research projects in the areas of production and transportation of hydropower and mainly the monitoring of large hydro turbines. Since 2001, he is senior scientist at the LMH laboratory, head of the cavitation group. He is also lecturer in Master and Doctoral programs. He is member of the Doctoral Committee in Mechanics.
