Concept

Function (biology)

Related publications (30)

Bioengineering human mini-intestines with in vivo-like complexity and function

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

EPFL2023

Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams

Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Tyler Joe Kohler, Stylianos Fodelianakis, Paraskevi Pramateftaki, Vincent Henri De Staercke, Matteo Tolosano, Michail Styllas, Martina Andrea Schön

In glacier-fed streams, ecological windows of opportunity allow complex microbial biofilms to develop and transiently form the basis of the food web, thereby controlling key ecosystem processes. Using metagenome-assembled genomes, we unravel strategies tha ...

Springer2022

Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1

Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Philipp Bucher, Maryse Fiche, Valentina Scabia, Patrik Aouad, Fabio De Martino

Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...

2021

Organohalide respiration: breakthrough towards the elucidation of the electron-accepting moiety of the respiratory chain

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

Background Organohalide respiration (OHR) is a bacterial anaerobic process in which chlorinated compound, e.g. tetrachloroethene (PCE), is used as terminal electron acceptors. Dehalobacter restrictus PER-K23, a paradigmatic organohalide-respiring bacterium ...

2021

Population pharmacokinetic model selection assisted by machine learning

Jan Sickmann Hesthaven, Nadia Terranova

A fit-for-purpose structural and statistical model is the first major requirement in population pharmacometric model development. In this manuscript we discuss how this complex and computationally intensive task could benefit from supervised machine learni ...

SPRINGER/PLENUM PUBLISHERS2021

90 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer

Cathrin Brisken, Valentina Scabia

Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...

BIOSCIENTIFICA LTD2020

Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

Kei Sakamoto, Maria Deak, Caterina Collodet

PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK) 16), is a Ser/Thr kinase that has been implicated in many cellular processes, including cell cycle, spermatogenesis, neurite outgrowth, and vesicle trafficking. Most recently, it has been propo ...

2019

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Florent François Masson, Juan Camilo Paredes Escobar, Mario Gonzalo Garcia Arraez

BackgroundInsects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic nature of such associations is put in ...

2019

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Drought can occur at different times during the grassland growing season, likely having contrasting effects on forage production when happening early or later in the season. However, knowledge about the interacting effects of the timing of drought and the ...

Oxford University Press (OUP)2019

Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior

Friedhelm Christoph Hummel

Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. R ...

Nature Publishing Group2018

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