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TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- a ...
Recently generated progesterone receptor (PR)-negative (PR-/-) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. However, the full extent of the mammary gland defec ...
A significant number of diploid oocytes is ovulated from adult NMRI/Han mice treated with high doses of gonadotrophins. This inhibition of the first meiotic division is very likely caused by an altered communication between the germ cell and the surroundin ...
The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling the organism to quickly adapt to environmental changes by inducing the appropriate metabolic genes and pathways. Ligands for these metabolic receptors are compounds from d ...
Homochiral Diels-Alder cyclodimerization of (+/-)-6-ethenyl-7-oxabicyclo[2.2.1]hept-5-en-2-endo-ol followed by oxidation gives (1RS,4RS,4aSR,4bSR,5RS,8RS,8aRS)-8a-ethenyl-1,3,4a,4b,5,6,8,8a,9-decahyd ro-11,4:5,8-diepoxyphenanthrene-2,7-dione (18). Selectiv ...
We describe here the biological screening of a collection of natural occurring triterpenoids against the G protein-coupled receptor TGR5, known to be activated by bile acids and which mediates some important cell functions. This work revealed that betulini ...
TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucose homeostasis. With the aim of disclosing novel selective modu ...
A common feature of many metabolic pathways is their control by retinoid X receptor (RXR) heterodimers. Dysregulation of such metabolic pathways can lead to the development of atherosclerosis, a disease influenced by both systemic and local factors. Here w ...
The Diels-Alder adduct 3 of 2,2'-ethylidenebis(3,5-dimethylfuran) to diethyl (E,E)-4-oxohepta-2,5-diene-1,7-dioate was converted into meso-(1R,2R,4R,4aR,5S,7S,8S,8aS,9aS,10aS)- 1,8-bis(acetoxymethyl)- 1,3,4,5,6,7,8,8a,9,9a-decahydro-2,4,5,7,10 -pentamethyl ...