Publications related to Lymphadenopathy

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the tumor microenvironment and in the tumor-draining lymph node. The mechanism unde ...

Amer Assoc Cancer Research2014

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Pedro Romero, Marie Ballester, Laura Jeanbart, Patricia Corthésy Henrioud

The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against ...

Amer Assoc Cancer Research2014

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Freddy Radtke, Ute Koch, Anne Wilson, Nicolas Fasnacht, Floriane Auderset

Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study ...

American Association of Immunologists2013

Epidermal {gamma}{delta} T cells sense precancerous cellular dysregulation and initiate immune responses

Freddy Radtke

Hyperplasia associated with a loss of tissue homeostasis can induce DNA replication stress, leading to precancerous dysregulation. Epidermal {gamma}{delta} T cells reside in the primary barrier that protects against diverse environmental insults; however, ...

Oxford University Press2010

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

Melody Swartz, Alice Anna Tomei

In the paracortex of the lymph node (LN), T zone fibroblastic reticular cells (TRCs) orchestrate an immune response by guiding lymphocyte migration both physically, by creating three-dimensional (3D) cell networks, and chemically, by secreting the chemokin ...

American Association of Immunologists2009

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype

Melody Swartz, Amine Issa

Most carcinomas spread to distant sites through lymphatic vessels. Several preclinical and clinical studies have shown a positive correlation between the incidence of lymph node metastasis and secretion of the lymphatic growth factor vascular endothelial g ...

American Association for Cancer Research2009

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

Melody Swartz, Alice Anna Tomei, Mark Fleury, Carolyn Yong Pullin

CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell migration by autocrine CCR7 signaling. Under static conditions, lymphatic ...

Elsevier2007

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Lymphadenopathy

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

Epidermal {gamma}{delta} T cells sense precancerous cellular dysregulation and initiate immune responses

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

Graph Chatbot

Chat with Graph Search

Epidermal {gamma}{delta} T cells sense precancerous cellular dysregulation and initiate immune responses

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?