Publications related to Endocytosis

A general mechanism for intracellular toxicity of metal-containing nanoparticles

Francesco Stellacci, Randy Patrick Carney

The assessment of the risks exerted by nanoparticles is a key challenge for academic, industrial, and regulatory communities worldwide. Experimental evidence points towards significant toxicity for a range of nanoparticles both in vitro and in vivo. Worldw ...

Royal Society of Chemistry2014

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Liliane Glauser, Elpida Tsika, Darren Moore, Klodjan Stafa, Amy Jones, Alessandra Musso

Mutations in LRRK2 cause autosomal dominant Parkinsons disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative proteinprotein interaction domains. Familial PD mutations alter the GTPase and kinase activity of L ...

Oxford University Press2014

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Françoise Gisou van der Goot Grunberg

The endoplasmic reticulum (ER) forms functional contacts with several cellular organelles and regulates processes such as mitochondrial fission. In a recent issue of Cell, Rowland et al. (2014) extend these findings to endosomes, showing that the ER contac ...

2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the ...

Oxford University Press2014

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

László Forró, Jean-Jacques Meister, Niccolo Piacentini, Chiara Gabella, Sylvia Jeney, Elena Bertseva, Alicia Carine Bornert

Plasma membrane tension and the pressure generated by actin polymerization are two antagonistic forces believed to define the protrusion rate at the leading edge of migrating cells [1-5]. Quantitatively, resistance to actin protrusion is a product of membr ...

Elsevier2014

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

Horst Vogel, Davide Demurtas, Luigino Grasso, Romain Wyss, Camille Wolf, Hans Wolfgang Grosse

Cells secrete extracellular vesicles (EVs) into their microenvironment that act as mediators of intercellulard communication under physiological conditions and in this context also actively participate in spreading various diseases. Large efforts are curre ...

Amer Chemical Soc2014

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

Georgios Sflomos

Smad anchor for receptor activation (SARA) is highly enriched on endocytic membranes via binding to phosphatidylinositol 3-phosphates through its FYVE (Fab1p-YOTB-Vps27p-EEA1) domain. SARA was originally identified as a protein that recruits non-phosphoryl ...

Nature Publishing Group2013

LRRK2 secretion in exosomes is regulated by 14-3-3

Elpida Tsika, Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the endocytic pathway. Here, we show that LRRK2 is released in extracellular microvesicles (i.e. exosomes) ...

Oxford University Press2013

Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles

Jutta Christine Wandrey, Shima Karimi, Nicola Tirelli

The natural turnover of free hyaluronic acid (HA) is predominantly based on its CD44-mediated internalisation in leukocytes. In a phagocytic cell model (RAW 264.7 murine macrophages) we here provide conclusive evidence that this receptor-mediated mechanism ...

Elsevier2013

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Endocytosis

A general mechanism for intracellular toxicity of metal-containing nanoparticles

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

LRRK2 secretion in exosomes is regulated by 14-3-3

Investigating Endocytic Pathways to the Endoplasmic Reticulum and to the Cytosol Using SNAP-Trap

Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles

Graph Chatbot

Chat with Graph Search

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Contact Angle at the Leading Edge Controls Cell Protrusion Rate

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Investigating Endocytic Pathways to the Endoplasmic Reticulum and to the Cytosol Using SNAP-Trap

Molecular and Dimensional Profiling of Highly Purified Extracellular Vesicles by Fluorescence Fluctuation Spectroscopy

LRRK2 secretion in exosomes is regulated by 14-3-3

Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles

A general mechanism for intracellular toxicity of metal-containing nanoparticles