Concept
STAT5
Related publications (8)
Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors
Many targeted cancer therapies fail to improve the overall survival of patients. Limitations involve low drug selectivity and the rapid development of resistance. Moreover, the majority of oncogenic drivers presently remain considered as undruggable as th ...
EPFL2020Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation
Brain aging and neurodegeneration are associated with prominent microglial reactivity and activation of innate immune response pathways, commonly referred to as neuroinflammation. One such pathway, the type I interferon response, recognizes viral or mitoch ...
Cell Press2017Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
Bruno Lemaitre, Nichole Broderick, Sveta Chakrabarti
Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely u ...
2009Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins
OBJECTIVE: Besides its predictive role in determining cardiovascular risk, C-reactive protein (CRP) may exert direct proatherogenic effects through proinflammatory properties. CRP is mainly produced by hepatocytes in response to interleukin-6 (IL-6) and is ...
2005