Related publications (448)

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Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...
Amer Assoc Advancement Science2024

Green hydrogen production using Shewanella oneidensis MR-1 bioanode and cuprous oxide-based photocathode

Michele Morgante

In recent years, many efforts have been made to find alternative renewable energy sources that can ideally replace the use of fossil fuels in all aspects. One of the new emerging energy technologies is the bioelectrochemical system, of which two types are ...
EPFL2024

Mechanisms and functions of protein S-acylation

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento R De Mesquita

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...
Berlin2024

Cold stress-induced autophagy and apoptosis disorders are mainly mediated by AMPK/PPAR/PI3K/AKT/mTOR pathways

Yao Tian, Di Sun, Yibo Zhang

Under cold stress, the processes of autophagy, apoptosis and energy metabolism are pivotal for sustaining energy and tissue balance. However, the molecular regulatory mechanisms and interactions underlying these processes are still largely unknown. In this ...
Amsterdam2024

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Juan Cruz Landoni Martin

Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l-Op ...
Springernature2024

Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

Asli Sahin

Microorganisms are essential for life on Earth, performing key roles in numerous biological processes. Their influence extends across a wide spectrum, from human health and ecological balance to advancements in biotechnology and industrial applications. Th ...
EPFL2024

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...
NATURE PORTFOLIO2023

Reoxidation of Reduced Peat Organic Matter by Dissolved Oxygen: Combined Laboratory Column‐Breakthrough Experiments and In‐Field Push‐Pull Tests

Meret Aeppli

Electron transfer to peat particulate organic matter (POM) as terminal electron acceptor (TEA) in anaerobic respiration has been hypothesized to lower methane emissions from peatlands by competitively suppressing methanogenesis and/or allowing for anaerobi ...
2023

Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

Sebastian Martin Waszak

Diffuse midline glioma (DMG) is a devastating pediatric brain tumor unresponsive to hundreds of clinical trials. Approximately 80% of DMGs harbor H3K27M oncohistones, which reprogram the epigenome to increase the metabolic profile of the tumor cells. We ha ...
2023

Information Theory in Transmembrane Transport

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The past decades have seen the advent of information theory in various fields, from quantum physics to cosmology.At an intermediary scale between atomic and cosmological scales are biological systems and in particular the cell, as a constitutive element of ...
EPFL2023

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