Publications related to Pinocytosis

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum

Henning Paul-Julius Stahlberg, Shyan Huey Low

Entry of the facultative intracellular pathogen Brucella into host cells results in the formation of endosomal Brucella-containing vacuoles (eBCVs) that initially traffic along the endocytic pathway. eBCV acidification triggers the expression of a type IV ...

The Company of Biologists2018

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

Michele De Palma, Mario Leonardo Squadrito, Chiara Cianciaruso, Sarah Kate Hansen

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated ...

2018

3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics

Theo Lasser, Paul James Marchand, Jérôme Extermann, Antonio Lopez, Miguel Sison, Amir Jean Nahas

We present a 3D time-lapse imaging method for monitoring mitochondrial dynamics in living HeLa cells based on photothermal optical coherence microscopy and using novel surface functionalization of gold nanoparticles. The biocompatible protein-based biopoly ...

Nature Publishing Group2017

Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

Henning Paul-Julius Stahlberg

Membrane proteins are vital to life and major therapeutic targets. Yet, understanding how they function is limited by a lack of structural information. In biological cells, membrane proteins reside in lipidic membranes and typically experience different bu ...

Walter de Gruyter GmbH2017

Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease

Hilal Lashuel, Anne-Laure Mahul Mellier, Nadine Aït Bouziad, Gizem Zorludemir

The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinan ...

Nature Publishing Group2017

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Marco Pisano, Valentina Triacca, Melody Swartz, Witold Waldemar Kilarski, Esra Güç

Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lippincott Williams & Wilkins2017

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Kai Johnsson, Rudolf Hovius, Rudolf Griss, Kui Thong Tan, Silvia Scarabelli

We are introducing a new approach to evaluate cellular uptake of drugs and drug candidates into living cells. The approach is based on converting the protein target of a given class of compounds into a fluorescent biosensor. By measuring the binding of dif ...

Amer Chemical Soc2017

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

Harm-Anton Klok, Claudia Battistella

Inhibition of P-glycoprotein (P-gp) transporter is an attractive approach for the reversion of cancer-associated multidrug resistance (MDR). Poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA)-based carriers that are able to release the anticancer drug doxoru ...

2017

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

Julian Charles Shillcock

The bacterial Shiga toxin is composed of an enzymatically active A-subunit, and a receptor-binding homopentameric B-subunit (STxB) that mediates intracellular toxin trafficking. Upon STxB-mediated binding to the glycolipid globotriaosylceramide (Gb3) at th ...

Royal Society of Chemistry2016

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Pinocytosis

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics

Elastic and dynamic properties of membrane phase-field models

Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

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Chat with Graph Search

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum

3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics

Elastic and dynamic properties of membrane phase-field models

Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

Discovery and characterization of novel stable tau oligomeric complexes: Implications for the role of Tau/phospholipid interactions in regulating its functions in health and disease

Reversion of P-gp-Mediated Drug Resistance in Ovarian Carcinoma Cells with PHPMA-Zosuquidar Conjugates

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation