Heinz HügliHeinz Hügli is professor emeritus at Ecole Polytechnique Federale de Lausanne (EPFL). He was a research director and associate professor at the Institute of Microtechnology, University of Neuchâtel, Switzerland, where he teached and headed the Pattern Recognition Laboratory (PARLAB). From 1988 to 2008, this lab was active in computer vision and pattern recognition with emphasis on early vision processing, industrial inspection, 3D object modeling and recognition.
Heinz Hügli received the Diploma in Electrical Engineering and Ph.D. degree from the Swiss Federal Institute of Technology in Zurich (EPFZ). He spent five year with the Image processing research group at EPFZ and later two years with the Medical Imaging Science Group, University of Southern California. In 1982 he joined the University of Neuchâtel were he first conducted speech recognition activities and then founded the PARLAB. He teached at the University of Neuchâtel, EPFL and University of Bern. Author of more than 150 scientific publications, he has chaired international conferences, was a member of several scientific societies, and participated in several conference program committees.
Nikolaos StergiopoulosEducation
MTE, Managing the Technology Enterprise Program (2000), IMD, Lausanne
Ph.D. in Biomedical Engineering & Engineering Mechanics (1990) Iowa State University, Ames, Iowa.
MS in Biomedical Engineering (1987) Iowa State University, Ames, Iowa.
Diploma in Mechanical Engineering (1985) National Technical University of Athens.
Professional Activities
2002 - present: Professor and director of LHTC
2010 - present: Founder and director of Rheon Medical SA, Préverenges, Switzerland
2008 - present: Founder and director of Antlia S.A., PSE-C, EPFL campus, Switzerland
1998 - 2007: Founder and Scientific Director of EndoArt S.A., Lausanne, Switzerland
1996 - 2002: Assistant professor at the Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne, Switzerland.
1991 - 1996: Research Associate at Swiss Federal Institute of Technology - Lausanne
1990 - 1991: Lecturer, Iowa State University
Nikolaos GeroliminisProf. Nikolas Geroliminis is an Associate Professor at EPFL and the head of the Urban Transport Systems Laboratory (LUTS). Before joining EPFL he was an Assistant Professor on the faculty of the Department of Civil Engineering at the University of Minnesota. He has a diploma in Civil Engineering from the National Technical University of Athens (NTUA) and a MSc and Ph.D. in civil engineering from University of California, Berkeley. He is an Associate Editor for Transportation Research part C and he also serves in the editorial board of TR, part B, Transportation Letters, Journal of ITS and of many international conferences. He is a member of the Transportation Research Board's Traffic Flow Theory Committee. His research interests focus primarily on urban transportation systems, traffic flow theory and control, public transportation and logistics, Optimization and Large Scale Networks. He is a recent recipient of the ERC Starting Grant METAFERW: Modeling and controlling traffic congestion and propagation in large-scale urban multimodal networks
Education
Diploma, 2003, Civil Engineering, National Technical University of Athens, Greece
M.S., 2004, Civil and Environmental Engineering, University of California at Berkeley
Ph.D., 2007, Civil and Environmental Engineering, University of California at Berkeley
Karl AbererKarl Aberer received his PhD in mathematics in 1991 from the ETH Zürich. From 1991 to 1992 he was postdoctoral fellow at the International Computer Science Institute (ICSI) at the University of California, Berkeley. In 1992, he joined the Integrated Publication and Information Systems institute (IPSI) of GMD in Germany, where he was leading the research division Open Adaptive Information Management Systems. In 2000 he joined EPFL as full professor. Since 2005 he is the director of the Swiss National Research Center for Mobile Information and Communication Systems (
NCCR-MICS, www.mics.ch
). He is member of the editorial boards of VLDB Journal, ACM Transaction on Autonomous and Adaptive Systems and World Wide Web Journal. He has been consulting for the Swiss government in research and science policy as a member of the Swiss Research and Technology Council (
SWTR
) from 2003 - 2011. Jean-Jacques MeisterA Swiss citizen, Jean-Jacques Meister was born in 1950. He received a diploma in electrical engineering, then a diploma in physics from the Swiss Federal Institute of Technology in Lausanne (EPFL). He joined the Institute of Biomedical Engineering at the Swiss Federal Institute of Technology in Zurich and obtained a PhD in1983. From 1984 to 1990, he worked in different areas of biophysics and biomedical engineering. His main contributions concern novel noninvasive methods for the prevention and diagnosis of cardiovascular diseases: mechanical properties of the arterial wall, arterial hemodynamics, and Doppler ultrasonography. In 1990, he was recruited as a full professor of experimental physics at the Swiss Federal Institute of Technology in Lausanne. He was director of the laboratory of biomedical engineering until 2001, then director of the laboratory of cell biophysics. His fields of research are cellular biophysics: cytoskeleton dynamics, motility & adhesion of cells and calcium dynamics in smooth muscle cells. He spent a sabbatical leave in 2000 at the famous Marine Biological Laboratory, Woods Hole, Massachusetts -USA to improve his skills in molecular and cellular biology. His teaching activities include courses in general physics, Newtonian mechanics, biomedical engineering and biophysics presented to undergraduate and graduate EPFL students in physics and engineering. He is author or co-author of more than 230 scientific papers & book chapters and 8 international patents.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Jean-Louis ScartezziniDirector of EPFL Solar Energy and Building Physics Laboratory (1994-present); Founder & Director of ENAC Institute of Infrastructures, Resources and Environment (2002-2009); Founder & Director of EPFL Doctoral Program in Environment (2002-2009); Co-Director of EPFL Institute of Building Technology (1994-1997); Associate Professor of Building Physics at EPFL (1994-1997); Associate Professor of Building Physics at University of Geneva (1990-1997); Group Leader & Research Fellow at the EPFL Solar Energy Research Group (1981-1989); Research Fellow at the Applied Geophysics Institute of University of Lausanne (1980-1981).
Alcherio MartinoliI received my Diploma in Electrical Engineering from the Swiss Federal Institute of Technology in Zurich (ETHZ), and a Ph.D. in Computer Science from the Swiss Federal Institute of Technology in Lausanne (EPFL). I am currently an Associate Professor at the School of Architecture, Civil, and Environmental Engineering and the head of the Distributed Intelligent Systems and Algorithms Laboratory. Before joining EPFL I carried out research activities at the Institute of Biomedical Engineering of the ETHZ, at the Institute of Industrial Automation of the Spanish Research Council in Madrid, Spain, and at the California Institute of Technology, Pasadena, U.S.A. Additional information can be found on my full CV.
Alfio QuarteroniOf italian nationality, Alfio Quarteroni was born on May 30th 1952. He pursued his studies in mathematics at University of Pavia and at University of Paris VI. In 1986 he was nominated full professor at Catholic University of Brescia, later professor in mathematics at University of Minnesota at Minneapolis and professor in numerical analysis at Politecnico di Milano. He is designated full professor in 1997 and enters into service with EPFL in 1998. At EPFL, he teaches numerical analysis to engineers and mathematicians and holds specialized courses about mathematical modelling and scientific computing for master and PhD students. He had been scientific director of CRS4, plenary speaker of more than two hundred international conferences; he is member of the European Academy of Sciences, the Italian Academy of Sciences, the Lombard Academy of Science and Letters. He is Editor in Chief of two book series (MS&A and Unitext) by Springer, associate editor of 25 international journals. He has been plenary speaker at the International Congress of Mathematicians ICM2006. He had been responsible of several European research networks. His team has carried out the aerodynamic and hydrodynamic simulations for the optimization of Alinghi, the Swiss sailing yacht that has won two editions of the America's Cup in 2003 and 2007.
