Concept

Transient receptor potential channel

Related publications (37)

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. beta-Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene expression by interacting with transcription factors of the TCF/LEF family. In the ...

2007

Insights into excited-state and isomerization dynamics of bacteriorhodopsin from ultrafast transient UV absorption

Majed Chergui, Frank van Mourik, Selma Schenkl

A visible-pump/UV-probe transient absorption is used to characterize the ultrafast dynamics of bacteriorhodopsin with 80-fs time resoln. We identify three spectral components in the 265- to 310-nm region, related to the all-trans retinal, tryptophan (Trp)- ...

2006

Control of daily transcript oscillations in Drosophila by light and the circadian clock

Felix Naef

The transcriptional circuits of circadian clocks control physiological and behavioral rhythms. Light may affect such overt rhythms in two ways: (1) by entraining the clock circuits and (2) via clock-independent molecular pathways. In this study we examine ...

Public Library of Science2006

Calcium dynamics and intercellular communication in arterial smooth muscle cells

Mathieu Lamboley

This thesis is a contribution to the field of cellular communication in arteries during vasomotion, i.e. rhythmic and spontaneous diameter oscillations of arteries. Investigating how individual smooth muscle cells (SMCs) and endothelial cells (ECs) calcium ...

EPFL2005

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Roger Sauser, Jean-Louis Bény, Michèle Koenigsberger, Philippe Pittet, Mathieu Lamboley

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005

Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter

Vassily Hatzimanikatis

The heat-shock response in humans and other eukaryotes is a highly conserved genetic network that coordinates the cellular response to protein damage and is essential for adaptation and survival of the stressed cell. It involves an immediate and transient ...

2005

Reduction of adenovirus E1A mRNA by RNAi results in enhanced recombinant protein expression in transiently transfected HEK293 cells

Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Martin Bertschinger

Human embryonic kidney 293 (HEK293) cells, a widely used host for large-scale transient expression of recombinant proteins, are transformed with the adenovirus E1A and E1B genes. Because the E1A proteins function as transcriptional activators or repressors ...

2004

Modelling the electrophysiological endothelial cell response to bradykinin

Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The goal of the present study is to construct a biophysical model of the coronary artery endothelial cell response to bradykinin. This model takes into account intracellular Ca2+ dynamics, membrane potential, a non-selective cation channel, and two Ca(2+)- ...

Springer-Verlag2003

Investigation of the carbon monoxide and oxy hemoglobin I complexes from Lucina pectinata by femtosecond transient absorption

Majed Chergui

Hb I (HbI) is an invertebrate monomeric hemeprotein from Lucina pectinata that contains 142 amino acid residues. The HbI heme pocket structural compn. shows an arrangement of phenylalanyl residues (Phe (29), Phe (43) and Phe (68)) that has not been obsd. i ...

2002

Total synthesis of the C-37-C-45 F-ring fragment of spongistatins

Pierre Vogel

The highly substituted F ring of Spongistatins was synthesized from (R)-(+)-3-benzyloxy-2-methylpropan-1-ol (5), using two sequential Sharpless dihydroxylations as key-steps. A 4-deoxy-4-methyl-D-threo-L-glucoheptopyranose derivative was obtained and could ...

1998

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