Concept

Most recent common ancestor

Related publications (69)

Contractile Tail Machines of Bacteriophages

Bacteriophages with contractile tails epitomize the concepts of "virus" and "phage" for many because the tails of these phages undergo a large conformational change - resembling the action of a syringe - upon the attachment to the host cell. The contractil ...

2012

The journey of resveratrol from yeast to human

Johan Auwerx

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...

2012

The journey of resveratrol from yeast to human

Johan Auwerx

2012

Chromatin as an expansive canvas for chemical biology

Beat Fierz

Chromatin is extensively chemically modified and thereby acts as a dynamic signaling platform controlling gene function. Chromatin regulation is integral to cell differentiation, lineage commitment and organism development, whereas chromatin dysregulation ...

2012

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

Patrick Aebischer, Bernard Schneider, Romain Zufferey, Olexiy Kochubey, Klodjan Stafa, Julien Dusonchet

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant proportion of both autosomal dominant familial and sporadic PD cases. Our aim in the present stu ...

Society for Neuroscience2011

Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

Bruno Lemaitre, Juan Camilo Paredes Escobar, David Welchman

Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidogly ...

2011

Protein-binding microarrays: probing disease markers at the interface of proteomics and genomics

Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod

DNA-binding proteins mediate a variety of crucial molecular functions, such as transcriptional regulation and chromosome maintenance, replication and repair, which in turn control cell division and differentiation. The roles of these proteins in disease ar ...

2009

Sustained Effects of Nonallele-Specific Huntingtin Silencing

Nicole Déglon

Objective: Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated ...

Wiley-Blackwell2009

Electromechanics on the Nanometer Scale: Emerging Phenomena, Devices, and Applications

Nava Setter

Coupling between electrical and mechanical phenomena is ubiquitous in nature and underpins the functionality of materials and systems as diversified as ferroelectrics and multiferroics to electroactive molecules to biological systems. Recent years have wit ...

2009

Conserved elements within open reading frames of mammalian Hox genes

Denis Duboule

A recent study in BMC Evolutionary Biology shows that many of the open reading frames in mammalian Hox genes are more conserved than expected on the basis of their protein sequence. The presence of highly conserved DNA elements is thus not confined to the ...

2009

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