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Topology Optimization of an Electromagnet Manipulator for 3D Uniform Magnetic Field Generation

Yves Perriard, Adrien Jean-Michel Thabuis, Maribel Caceres Rivera, Xiaotao Ren

Magnetic manipulation is a method used for biomedical applications to remotely control micro-robots in a contactless manner. The electromagnet manipulator should control a magnetic field with 3 degrees of freedom inside a region of interest. In various cas ...

Institute of Electrical and Electronics Engineers2023

Modeling lightning strikes to tall towers

Farhad Rachidi-Haeri, Marcos Rubinstein

In this chapter, we present a review of recent progress in the modeling of lightning strikes to tall structures. Since some tall structures are struck by lightning several tens of times per year, they can be used as ground-truth to measure and calibrate th ...

IET2023

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Bruno Emanuel Ferreira De Sousa Correia, Anthony Marchand, Alexandra Krina Van Hall-Beauvais

Protein–protein interactions (PPIs) govern numerous cellular functions in terms of signaling, transport, defense and many others. Designing novel PPIs poses a fundamental challenge to our understanding of molecular interactions. The capability to robustly ...

2022

Computational design of vaccine immunogens

Bruno Emanuel Ferreira De Sousa Correia, Andreas Scheck, Karla Montserrat Castro Gilabert, Shuhao Xiao

Computational protein engineering has enabled the rational design of customized proteins, which has propelled both sequence-based and structure-based immunogen engineering and delivery. By discerning antigenic determinants of viral pathogens, computational ...

CURRENT BIOLOGY LTD2022

Computational tools and resources for designing new pathways to small molecules

Vassily Hatzimanikatis, Anastasia Sveshnikova

The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the ...

CURRENT BIOLOGY LTD2022

Reconstruction of the Hippocampus

Henry Markram, Armando Romani, Felix Schürmann, Michele Migliore

The hippocampus is a widely studied brain region thought to play an important role in higher cognitive functions such as learning, memory, and navigation. The amount of data on this region increases every day and delineates a complex and fragmented picture ...

Springer2022

EUROfusion-theory and advanced simulation coordination (E-TASC): programme and the role of high performance computing

Laurent Villard, Jonathan Graves, Eric Serre

This paper is a written summary of an overview oral presentation given at the 1st Spanish Fusion High Performance Computer (HPC) Workshop that took place on the 27 November 2020 as an online event. Given that over the next few years ITER24 will move to its ...

2022

On Succinct Non-interactive Arguments in Relativized Worlds

Alessandro Chiesa

Succinct non-interactive arguments of knowledge (SNARKs) are cryptographic proofs with strong efficiency properties. Applications of SNARKs often involve proving computations that include the SNARK verifier, a technique called recursive composition. Unfort ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Computational Studies of the Proton-Coupled Metal Ion Transport in the SLC11/NRAMP Family of Transporters

Maria Letizia Merlini

In the last years, it has been demonstrated a link between the overload of metal ions inside nervous system cells and the onset of severe neurodegenerative diseases. This prompted the investigation of the structural and functional properties of transporter ...

EPFL2022

Spatio-Temporal Estimation of Renewable Energy Potential in Built Environments using Big Data

Alina Ursula Rosa Walch

To achieve the goals of the Paris Agreement on climate change, governments around the world must shift to renewable energy (RE) to drastically reduce their CO2 emissions within the next 10-30 years. The development of effective strategies for RE integratio ...

EPFL2022

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