Publications related to Closed-head injury

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

Erick Jorge Canales Rodriguez, Marco Pizzolato, Tim Bjørn Dyrby

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherica ...

ELSEVIER2023

Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss

Adriano Bernini, Ricardo Alberto Corredor Jerez, Neil Graham

Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor outcome. However, the exact pathophysiological mechanisms underlying this ...

MARY ANN LIEBERT, INC2022

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Pierre Magistretti

Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...

FRONTIERS MEDIA SA2019

Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patients

Sarah Catherine Sonnay, Anirikh Chakrabarti, Mojgan Masoodi, Nicolas Christinat

Background: Traumatic brain injury (TBI) is recognized as a metabolic disease, characterized by acute cerebral glucose hypo-metabolism. Adaptive metabolic responses to TBI involve the utilization of alternative energy substrates, such as ketone bodies. Cer ...

ELSEVIER SCIENCE BV2019

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Pierre Magistretti, Jocelyne Bloch

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. Design: Prospec ...

LIPPINCOTT WILLIAMS & WILKINS2018

Central nervous system microbleeds in the acute phase are associated with structural integrity by DTI one year after mild traumatic brain injury: A longitudinal study

Jean-Philippe Thiran, David Paul Roger Romascano, Alessandro Daducci, Pietro Bontempi

Introduction: Several imaging modalities are under investigation to unravel the pathophysiological mystery of delayed performance deficits in patients after mild traumatic brain injury (mTBI). Although both imaging and neuropsychological studies have been ...

ELSEVIER URBAN & PARTNER SP Z O O2018

Sympathetic activity and early mobilization in patients in intensive and intermediate care with severe brain injuries: a preliminary prospective randomized study

Dimitri Nestor Alice Van De Ville

Background: Patients who experience severe brain injuries are at risk of secondary brain damage, because of delayed vasospasm and edema. Traditionally, many of these patients are kept on prolonged bed rest in order to maintain adequate cerebral blood flow, ...

BioMed Central2016

Diagnostic approaches to predict persistent post-traumatic symptoms after mild traumatic brain injury - a literature review

Jean-Philippe Thiran, Alessandro Daducci

Mild traumatic brain injury (mTBI) is one of the most frequently diagnosed neurological disorders in emergency departments. Although there are established recommendations for the diagnosis and treatment in the acute stage, there is an on-going debate in wh ...

Taylor & Francis Ltd2016

Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate

Pierre Magistretti, Jocelyne Bloch, Luc Pellerin

Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined a ...

Mary Ann Liebert2015

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