Concept
Oligonucleotide synthesis
Related publications (66)
Solid-phase peptide synthesis in 384-well plates
Christian Heinis, Edward Jeffrey Will, Anne Sofie Luise Zarda, Alexander Lund Nielsen, Sevan Mleh Habeshian, Mischa Schüttel, Gontran Sangouard
Newer solid-phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification. However, the maximum number of peptides that ...
Hoboken2024Recycling of Polymerase Chain Reaction (PCR) Kits
Francesco Stellacci, Weina Liu, Yong Zhu
Polymerase chain reaction (PCR) kits have been used as common diagnosing tools during the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with daily worldwide usage in the millions. It is well known that at the beginn ...
AMER CHEMICAL SOC2023Optimised set of oligonucleotides for bulk rna barcoding and sequencing
Bart Deplancke, Vincent Roland Julien Gardeux, Riccardo Dainese, Daniel Alpern
The present invention relates generally to the field of nucleic acid sequencing and provides oligonucleotide molecules and barcodes contained therein. These oligonucleotide molecules and barcodes molecules are useful in sequencing to identify and resolve e ...
2023RNA-based nanomedicines and their clinical applications
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endo ...
Beijing2023Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Sevan Mleh Habeshian, Ying Zhang
Libraries of DNA-Encoded small molecules created using combinatorial chemistry and synthetic oligonucleotides are being applied to drug discovery projects across the pharmaceutical industry. The majority of reported projects describe the discovery of rever ...
PERGAMON-ELSEVIER SCIENCE LTD2021Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides
Christian Heinis, Van Manh Pham
DNA-encoded chemical library technologies enable the screening of large combinatorial libraries of chemically and structurally diverse molecules, including short cyclic peptides. A challenge in the combinatorial synthesis of cyclic peptides is the final st ...
2019Compositions and methods for delivering nucleic acids to cochlear and vestibular cells
Bernard Schneider, Paola Andrea Solanes Vega
Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. ...
2019Aptamer Recognition of Multiplexed Small-Molecule-Functionalized Substrates
Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabilities. We investigated recognition of substrate-tethered small-molecule targets, using neurotransmitters as examples, and fluorescently labeled DNA aptamers. ...
2018Xeno Nucleic Acid Nanosensors for Enhanced Stability Against Ion-Induced Perturbations
Ardemis Anoush Boghossian, Carlo Gigli, Alice Judith Gillen, Justyna Kupis-Rozmyslowicz
The omnipresence of salts in biofluids creates a pervasive challenge in designing sensors suitable for in vivo applications. Fluctuations in ion concentrations have been shown to affect the sensitivity and selectivity of optical sensors based on single-wal ...
2018Nucleoside Analogues: Synthesis from Strained Rings
Jérôme Waser, Jérémy Vuilleumier, Sophie Lucie Racine
Nucleoside analogues are widely employed as bioactive compounds against cancer and viral infections. Consequently, it is important to develop efficient synthetic methods to access them with high efficiency and structural diversity. Herein, we present a ful ...
Wiley-V C H Verlag Gmbh2016