Second Mesa is a census-designated place (CDP) in Navajo County, Arizona, on the Hopi Reservation, atop the 5,700-foot (1,740 m) mesa. As of the 2010 census, the CDP population was 962, spread among three Hopi Indian villages, Musungnuvi (or Mishongnovi), Supawlavi (or Sipaulovi), and Songoopavi (or Shungopavi). The Hopi Cultural Center is on Second Mesa.
Second Mesa is located at (35.817613, -110.504281).
According to the United States Census Bureau, the CDP has a total area of .
At the 2000 census there were 814 people, 209 households, and 169 families in the CDP. The population density was . There were 255 housing units at an average density of 9.6/sq mi (3.7/km^2). The racial makeup of the CDP was 97% Native American, 1% White,