Concept
Isozyme
Related publications (11)
Revealing chromatin-specific functions of histone deacylases
Beat Fierz, Carlos Moreno Yruela
Histone deacylases are erasers of Nε-acyl-lysine post-translational modifications and have been targeted for decades for the treatment of cancer, neurodegeneration and other disorders. Due to their relatively promiscuous activity on peptide substrates in v ...
2024A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism
Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis
We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...
Academic Press Inc Elsevier Science2016Low-cost industrially available molybdenum boride and carbide as “platinum-like” catalysts for the hydrogen evolution reaction in biphasic liquid systems
Hubert Girault, Xile Hu, Kurt Schenk, Heron Vrubel, Micheal Diarmaid Scanlon, Véronique Amstutz
Rarely reported low-cost molybdenum boride and carbide microparticles, both of which are available in abundant quantities due to their widespread use in industry, adsorb at aqueous acid–1,2-dichloroethane interfaces and efficiently catalyse the hydrogen ev ...
Royal Soc Chemistry2013Small Molecule Based Approaches to Inhibit Macrophage Migration Inhibitory Factor (MIF) Activities and Elucidate its Role in Health and Disease
Macrophage migration inhibitory factor (MIF) is a major mediator in innate immunity and inflammation and a potential therapeutic target in multiple inflammatory, infectious and autoimmune diseases including cancer. Current therapeutic strategies for target ...
EPFL2010Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis
Matthias Lütolf, Jeffrey Alan Hubbell, Yun Suk Jo, Jay Gantz
We present a versatile scheme to rationally modulate the hydrolysis rate of ester bonds in hydrophilic polymer networks via adjacent charged amino acids. As soluble model systems, two cysteine-bearing oligopeptides containing either positively charged argi ...
2009Inducibility of Drug-metabolizing Enzymes by Xenobiotics in Mice with Liver-specific Knockout of Ctnnb1
Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expressio ...
2009Purification of an epoxide hydrolase from Rhodotorula glutinis
The epoxide hydrolase from Rhodotorula glutinis was isolated and initially characterized. The enzyme was membrane associated and could be solubilized by Triton X-100. Purification yielded an enzyme with sp. act. of 66 mu mol 1,2-epoxyhexane hydrolyzed min( ...
1999MCA has more to say
A review with many refs. The recent development of two math. frameworks for the anal. and design of metabolic systems is reviewed here with many refs. Both frameworks employ a (log)linear kinetic metabolic model that is constructed making direct, explicit ...
1996Cloning, localization and induction of mouse brain glycogen synthase
Pierre Magistretti, Jean-Luc Martin
The cDNA for mouse brain glycogen synthase has been isolated by screening a mouse cerebral cortical astrocyte lambda ZAP II cDNA library. The mouse brain glycogen synthase cDNA is 3.5 kilobases in length and encodes a protein of 737 amino acids. The coding ...
1996Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
Pierre Magistretti, Luc Pellerin
In vertebrates, the interconversion of lactate and pyruvate is catalyzed by the enzyme lactate dehydrogenase. Two distinct subunits combine to form the five tetrameric isoenzymes of lactate dehydrogenase. The LDH-5 subunit (muscle type) has higher maximal ...
1996