Publications related to Cytopathic effect

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

Jacques Fellay, Zhi Ming Xu, Dylan Lawless, Thomas Junier

Background. Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection. Methods. Among healthy term infants we identified those with prolonged RSV infection and c ...

OXFORD UNIV PRESS INC2023

Host genomics of SARS-CoV-2 infection

Jacques Fellay, Christian Axel Wandall Thorball

SARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical presentation of acute infection varies greatly between individuals, ranging from asymptomatic or mild to life-threatening COVID-19 pneumonia with multi-organ complications. De ...

SPRINGERNATURE2022

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

Henning Paul-Julius Stahlberg, David Hacker, Florence Pojer, Dongchun Ni, Kelvin Ka Ching Lau

The human membrane protein Angiotensin-converting enzyme 2 (hACE2) acts as the main receptor for host cells invasion of the new coronavirus SARS-CoV-2. The viral surface glycoprotein Spike binds to hACE2, which triggers virus entry into cells. As of today, ...

2020

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population ...

Springer2019

Multi-resistance of human enterovirus to UV-C disinfection and mutagenic nucleoside analogs

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong

Disinfection is an important strategy to control the environmental transmission of human viruses. Specifically, UV254 is increasingly used to disinfect from clinical items or surfaces to drinking water. RNA virus populations have high mutation rates and la ...

2016

Virus disinfection mechanisms: the role of virus composition, structure, and function

Tamar Kohn, Krista Rule Wigginton

Drinking waters are treated for enteric virus via a number of disinfection techniques including chemical oxidants, irradiation, and heat, however the inactivation mechanisms during disinfection remain elusive. Due to the fact that a number of significant w ...

Elsevier Sci Ltd2012

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

Henning Paul-Julius Stahlberg

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a me ...

Elsevier BV2012

The role of the inflammasome in cellular responses to toxins and bacterial effectors

Françoise Gisou van der Goot Grunberg

Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate in ...

Springer-Verlag2007

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Cytopathic effect

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

Host genomics of SARS-CoV-2 infection

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Virus transfer at the skin-liquid interface and its associated risks

Multi-resistance of human enterovirus to UV-C disinfection and mutagenic nucleoside analogs

Virus disinfection mechanisms: the role of virus composition, structure, and function

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

The role of the inflammasome in cellular responses to toxins and bacterial effectors

Graph Chatbot

Chat with Graph Search

Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort

Virus transfer at the skin-liquid interface and its associated risks

Virus disinfection mechanisms: the role of virus composition, structure, and function

Structural investigation of ACE2 dependent disassembly of the trimeric SARS-CoV-2 Spike glycoprotein

Host genomics of SARS-CoV-2 infection

The role of the inflammasome in cellular responses to toxins and bacterial effectors

Multi-resistance of human enterovirus to UV-C disinfection and mutagenic nucleoside analogs

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection