Trenton is a city in Gilchrist County, Florida, United States. The population was 1,999 as of the 2010 census, and in 2018 it was estimated to be 2,125. It is the county seat of Gilchrist County.
Trenton is located near the southern border of Gilchrist County at (29.615081, –82.817732). U.S. Route 129 is the city's Main Street; it leads north to Branford and south to Chiefland. Florida State Road 26 (Wade Street) leads east to Newberry and to Gainesville, while to the west it leads to Fanning Springs. Florida State Road 47 (Trenton Boulevard) intersects US 129 in the northern part of Trenton and leads northeast to Lake City.
According to the United States Census Bureau, the city of Trenton has a total area of , all land.
Trenton is in a rural area and is the hometown of country music singer Easton Corbin. The Florida Department of Corrections' nearby Lancaster Correctional Institution is from Trenton.