Concept

PEGylation

Related publications (19)

Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain

Firstly, this thesis presents the in vivo evaluation of a previously developed model system that utilizes CD4+ TE/M cells decorated with up to 100 polystyrene based nanoparticles per cell by maleimide thiol conjugation. These nanoparticle T-cell conjugates ...

EPFL2020

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Davide Demurtas

Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...

PUBLIC LIBRARY SCIENCE2020

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

Davide Demurtas

The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the o ...

Elsevier Science Bv2015

Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation

Harm-Anton Klok, Maarten Danial

Peptides derived from the HR1 or HR2 regions of the HIV-1 envelope glycoprotein gp41 have been shown to be effective inhibitors to prevent virus-host cell membrane fusion. These peptide drugs, however, suffer from relatively short plasma half-lives and are ...

Amer Chemical Soc2012

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Conlin O'Neil, Karen Dane, Jackson Eby

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Hybrid Polymer Foams for Osteochondral Tissue Engineering

Matthieu Cuénoud

Articular cartilage is a soft tissue that covers the ends of articulating bones, and is essential for maintaining joint motion, i.e. translation and rotation between the bones. Articular cartilage nevertheless has a limited capacity for self-repair, and ca ...

EPFL2012

Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Harm-Anton Klok, Florian Maria Wurm, David Hacker, Lucia Baldi Unser, Yashas Rajendra, Zuzana Kadlecova

The feasibility of a new transfection agent, HBPL, for the production of recombinant IgG antibody via TGE as well as for the transfection of primary cells is studied. Under the conditions investigated, transfection of CHO-DG44 cells using HBPL results in I ...

2012

Combating HIV Type 1 with Peptide - Synthetic Polymer Conjugates

Maarten Danial

Polymer therapeutics is a class of (bio)hybrid materials that include a plethora of biologically active (synthetic) macromolecules that either consist of polymeric drugs, drug-polymer conjugates, peptide/protein-polymer conjugates or of drug, peptide or pr ...

EPFL2011

Hepatitis C pharmacogenetics: state of the art in 2010

In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were ...

2011

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