Concept
Fat
Related publications (85)
Mechanisms and functions of protein S-acylation
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento R De Mesquita
Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...
Berlin2024Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal
João Miguel das Neves Duarte, Adélaïde Alice Mohr
Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. Howe ...
INT SOC AGING & DISEASE2022Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans
Richardus Houtkooper, Wen Gao, Yuan Liu
Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...
NATURE PORTFOLIO2022Colchicine stimulates browning via antagonism of GABA receptor B and agonism of? 3-adrenergic receptor in 3T3-L1 white adipocytes
Colchicine has been used for therapeutic purposes and has attracted considerable attention because of its association with tubulin and the inhibition of small tubular polymerization. Although several studies have examined the possible preventive role of co ...
ELSEVIER IRELAND LTD2022Trans‐seeding of Alzheimer‐related tau protein by a yeast prion
Henning Paul-Julius Stahlberg, Zhiva Skachokova
Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...
2022Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence
Objectives To determine and compare the qualitative and quantitative diagnostic performance of a single sagittal fast spin echo (FSE) T2-weighted Dixon sequence in differentiating benign and malignant vertebral compression fractures (VCF), using multiple r ...
SPRINGER2021Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Pooja Jha
How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...
NATURE PORTFOLIO2021Developing a high capacity axis translation apparatus for gas shale testing
Lyesse Laloui, Alessio Ferrari, Jinwoo Kim
Gas shales are usually partially saturated due to hydrocarbon generation and often have a low in-situ degree of saturation less than 40 %. During stimulation, substantial fluid imbibition into the formation occurs due to high suction. Recent research on th ...
EDP Sciences2020PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle
Johan Auwerx, Hao Li, Daniel Garcia
Rapid alterations in cellular metabolism allow tissues to maintain homeostasis during changes in energy availability. The central metabolic regulator acetyl-CoA carboxylase 2 (ACC2) is robustly phosphorylated during cellular energy stress by AMP-activated ...
CELL PRESS2020Nutrients influence seasonal metabolic patterns and total productivity of Arctic streams
The seasonality of gross primary production (GPP) in streams is driven by multiple physical and chemical factors, yet incident light is often thought to be most important. In Arctic tundra streams, however, light is available in saturating amounts througho ...
2020