Swayzee is a town in Sims Township, Grant County, Indiana, United States. The population was 981 at the 2010 census.
On its welcome sign, Swayzee claims to be "the only Swayzee in the world." This motto is based on a story about a postcard sent by a serviceman overseas during World War II, which although being addressed only to "Swayzee", with no mention of Indiana or any other information, was still said to have been successfully delivered.
James Swayzee was the original owner of the town site.
Pipe Creek Sinkhole, uncovered in 1996 at the Pipe Creek Junior limestone quarry near Swayzee, has been the site of important paleontological discoveries dating from the Pliocene epoch.
Swayzee is located at (40.506875, -85.825252) approximately eight miles west of the city of Marion. State Road 13 passes north and south through town along Washington Street, and State Road 22/Route 35 runs east and west about two & half mile south of town.