Concept

Toll-like receptor 4

Related publications (107)

In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults

The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions via the selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway ...

American Society for Biochemistry and Molecular Biology2004

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

Bruno Lemaitre

The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific antimicrobial peptide genes. We have determined the crys ...

2004

Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome

Etienne Meylan

Activation of caspase-1 and subsequent processing and secretion of the pro-inflammatory cytokine IL-1beta is triggered upon assembly of the inflammasome complex. It is generally believed that bacterial lipopolysaccharides (LPS) are activators of the inflam ...

Elsevier2004

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

Stewart Cole

The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cel ...

2003

The Drosophila immune system detects bacteria through specific peptidoglycan recognition

Bruno Lemaitre

The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway ...

Nature Publishing Group2003

A Scalable Routing Scheme for Self-Organized Terminode Network

Jean-Yves Le Boudec, Ljubica Blazevic

The focus of this paper is routing in a wide area mo-bile ad hoc network referred to as a Terminode Network. Our routing scheme is a combination of two protocols: Terminode Local Routing (TLR) and Terminode Remote Routing (TRR). TRR is used for rem ote des ...

2002

A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade

Bruno Lemaitre

The inducible production of antimicrobial peptides is a major immune response in Drosophila. The genes encoding these peptides are activated by NF-kappaB transcription factors that are controlled by two independent signaling cascades: the Toll pathway that ...

Elsevier2002

Drosophila immunity: two paths to NF-kappaB

Bruno Lemaitre

Recent studies of Drosophila immune responses have defined the immune deficiency (IMD) signaling pathway that mediates defense against Gram-negative bacterial infection. Like the Toll pathway, the IMD pathway regulates antimicrobial peptide gene expression ...

Elsevier2001

Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia

Bruno Lemaitre

The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities are synthesized by the fat body during the immune response and secr ...

Elsevier2000

The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

Françoise Gisou van der Goot Grunberg

Herein, we show that TNF exerts a pH-dependent increase in membrane conductance in primary lung microvascular endothelial cells and peritoneal macrophages. This effect was TNF receptor-independent, since it also occurred in cells isolated from mice deficie ...

1999

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