Publications related to Mild cognitive impairment

The population of developed countries is aging at an ever increasing rate. Even in the absence of neurodegenerative diseases, aging affects perceptual and cognitive functions that are crucial for everyday life. The effects of healthy aging on cognitive abi ...

2017

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Hilal Lashuel, Magdalena Zweckstetter, Michael Heinrich

α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of th ...

Oxford University Press2017

Large-scale functional network reorganization in 22q11.2 deletion syndrome revealed by modularity analysis

Dimitri Nestor Alice Van De Ville, Maude Schneider, Marie Schaer, Jonas Richiardi, Fikret Isik Karahanoglu

The 22q11.2 deletion syndrome (22q11DS) is associated with cognitive impairments and a 41% risk of developing schizophrenia. While several studies performed on patients with 22q11DS showed the presence of abnormal functional connectivity in this syndrome, ...

Elsevier Masson2016

Brain network characterization of high-risk preterm-born school-age children

Jean-Philippe Thiran, Alessandra Griffa, Elda Fischi Gomez, François Lazeyras

Higher risk for long-term cognitive and behavioral impairments is one of the hallmarks of extreme prematurity (EP) and pregnancy-associated fetal adverse conditions such as intrauterine growth restriction (IUGR). While neurodevelopmental delay and abnormal ...

Elsevier Sci Ltd2016

Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease

Dimitri Nestor Alice Van De Ville, Jonas Richiardi

Interindividual variation in neurovascular reserve and its relationship with cognitive performance is not well understood in imaging in neurodegeneration. We assessed the neurovascular reserve in amnestic mild cognitive impairment (aMCI) and Alzheimer's de ...

Elsevier2015

An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease

Meritxell Bach Cuadra, Bénédicte Marie Maréchal, Delphine Ribes Lemay, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Gunnar Krüger, Alexis Roche, Ahmed Abdulkadir

Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer’s disease (AD) related brain atrophy and to enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI) and e ...

Elsevier2015

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Meritxell Bach Cuadra, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Alexis Roche, Guillaume Bonnier

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...

Elsevier2015

Apathy and noradrenaline: silent partners to mild cognitive impairment in Parkinson's disease?

Kerstin Preuschoff, Leyla Loued-Khenissi

Purpose of review Mild cognitive impairment (MCI) is a comorbid factor in Parkinson's disease. The aim of this review is to examine the recent neuroimaging findings in the search for Parkinson's disease MCI (PD-MCI) biomarkers to gain insight on whether MC ...

Lippincott, Williams & Wilkins2015

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Laetitia Danielle Philippine Baud, Isabel Laura Vollenweider

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

Biomed Central Ltd2015

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Mild cognitive impairment

A factorial approach in aging research

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

Large-scale functional network reorganization in 22q11.2 deletion syndrome revealed by modularity analysis

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Brain network characterization of high-risk preterm-born school-age children

Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease

An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Apathy and noradrenaline: silent partners to mild cognitive impairment in Parkinson's disease?

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Graph Chatbot

Chat with Graph Search

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

A factorial approach in aging research

Large-scale functional network reorganization in 22q11.2 deletion syndrome revealed by modularity analysis

Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer's Disease Therapeutic Tools

Brain network characterization of high-risk preterm-born school-age children

An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease

Apathy and noradrenaline: silent partners to mild cognitive impairment in Parkinson's disease?

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression