In the field of chemical biology, a chemical probe is a small molecule that is used to study and manipulate a biological system such as a cell or an organism by reversibly binding to and altering the function of a biological target (most commonly a protein) within that system. Probes ideally have a high affinity and binding selectivity for one protein target as well as high efficacy. By changing the phenotype of the cell, a molecular probe can be used to determine the function of the protein with which it interacts.
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Chemical biology is a key discipline in biomedical research for drug discovery, synthetic biology and protein functional annotation. We will give a broad perspective of the field ranging from seminal