Concept
Granulosa cell
Related publications (15)
90 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer
Cathrin Brisken, Valentina Scabia
Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...
BIOSCIENTIFICA LTD2020Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture
Francesco Stellacci, Quy Ong Khac, Ahmet Bekdemir, Zhi Luo
Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples fr ...
2020Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection
The orphan nuclear receptor, liver receptor homolog-1 (aka Nuclear receptor subfamily 5, Group A, Member 2 (Nr5a2)), is widely expressed in mammalian tissues, and its ovarian expression is restricted to granulosa cells of activated follicles. We employed t ...
Society for the Study of Reproduction2017Culture of preantral follicles in poly(ethylene) glycol-based, three-dimensional hydrogel: a relationship between swelling ratio and follicular developments
Jeffrey Alan Hubbell, Seung Tae Lee
This study was undertaken to examine how the softness of poly(ethylene) glycol (PEG)-based hydrogels, creating a three-dimensional (3D) microenvironment, influences the in vitro growth of mouse ovarian follicles. Early secondary, preantral follicles of 2we ...
Wiley-Blackwell2015Murine ovarian follicle culture in PEG-hydrogel: Effects of mechanical properties and the hormones FSH and LH on development
Jeffrey Alan Hubbell, Seung Tae Lee, Jong Eun Ihm
The development of an in vitro culture system, comparable to the in vivo environment in terms of effects on oocyte growth and development, could provide a valuable experimental tool for studying the mechanisms governing oocyte development as well as practi ...
Polymer Soc Korea2015Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis
Cathrin Brisken, Kathryn Hess Bellwald
Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...
2015The Orphan Nuclear Receptor Nr5a2 Is Essential for Luteinization in the Female Mouse Ovary
In the ovary, the follicular granulosa cells express the nuclear receptor Nr5a2 (nuclear receptor subfamily 5 group A member 2), also known as liver receptor homolog-1, and after ovulation, Nr5a2 expression persists in the corpus luteum. Previous studies d ...
Endocrine Soc2014Liver receptor homolog-1 is essential for pregnancy
Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis(1). It is strongly expres ...
Nature Publishing Group2013Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery
Bruno Lemaitre, Fanny Schüpfer, Juan Camilo Paredes Escobar, Jeremy Keith Herren
Spiroplasma is a diverse bacterial clade that includes many vertically transmitted insect endosymbionts, including Spiroplasma poulsonii, a natural endosymbiont of Drosophila melanogaster. These bacteria persist in the hemolymph of their adult host and exh ...
American Society for Microbiology2013