Concept
HDAC1
Related publications (34)
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases
Carlos Moreno Yruela, Alexander Lund Nielsen, Di Zhang
Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. While K(L-la) ...
2022Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet ...
2021Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration
Multiple studies have found that increasing histone acetylation by means of histone deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode of action is not fully understood. In particular, it is uncle ...
2020The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo
Johan Auwerx, Lulu Liu, Wei Zhang, Yao Zhang, Na Zhang
Enhanced understanding of normal and malignant hematopoiesis pathways should facilitate the development of effective clinical treatment strategies for hematopoietic malignancies. Nuclear receptor corepressor 1 (NCoR1) has been implicated in transcriptional ...
AMER SOC HEMATOLOGY2019Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment
Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Ume-Gulsoom Abdul, Marije Trudi Te Winkel
Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs ...
Springer Verlag2017FORMINg a link between PTSD and AD
Epidemiological evidence suggests that people suffering from post-traumatic stress disorder have a higher risk for developing Alzheimer's disease. The underlying mechanisms, however, remained thus far unexplored. In this issue of The EMBO Journal, Agis-Bal ...
Nature Publishing Group2017The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression
Pierre Magistretti, Jean-René Cardinaux
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...
Elsevier2016Valproic acid potentiates the anticancer activity of capecitabine <i>in vitro</i> and <i>in vivo</i> in breast cancer models via induction of thymidine phosphorylase expression
The prognosis of patients with metastatic breast cancer remains poor, and thus novel therapeutic approaches are needed. Capecitabine, which is commonly used for metastatic breast cancer in different settings, is an inactive prodrug that takes advantage of ...
2016A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation
Didier Trono, Evaristo Jose Planet Letschert, Marco Cassano, Suk Min Jang
The transcriptional activator MyoD serves as a master controller of myogenesis. Often in partnership with Mef2 (myocyte enhancer factor 2), MyoD binds to the promoters of hundreds of muscle genes in proliferating myoblasts yet activates these targets only ...
Cold Spring Harbor Lab Press, Publications Dept2015