Concept

HDAC1

Related publications (34)

Unconventional Catalytic Mechanism for histone deacetylase suggested by a DFT-QM/MM study

Histone deacetylases (HDACs) constitute an important family of zinc-dependent enzymes responsible for catalyzing the cleavage of acetyl groups from acetyl-lysine residues in histone N-terminal tails. HDACs can potentially play a key role treating various c ...

2006

The CELO adenovirus Gam1 protein enhances transient and stable recombinant protein expression in Chinese hamster ovary cells

Florian Maria Wurm, David Hacker

The Gam1 protein of the avian CELO adenovirus activates transcription through inhibition of histone deacetylase 1 (HDAC1). We investigated the effect of Gam1 on both transient and stable transgene expression in Chinese hamster ovary (CHO) cells, one of the ...

2005

PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner

Johan Auwerx

The nuclear receptor PPARgamma is implicated in the control of cell proliferation and apoptosis. However, the molecular mechanisms by which it controls these processes remain largely elusive. We show here that PPARgamma activation in the presence of the re ...

2003

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

Johan Auwerx

The retinoblastoma protein (RB) has previously been shown to facilitate adipocyte differentiation by inducing cell cycle arrest and enhancing the transactivation by the adipogenic CCAAT/enhancer binding proteins (C/EBP). We show here that the peroxisome pr ...

2002

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