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The development of a low-cost, robust, and versatile biosensors for the rapid detection of endogenous and exogenous metabolites in small animals is of great interest for health-care, pharmaceuticals, and in translational medicine. This work presents a comp ...
The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain 'orphan' proteases, among them ADAMTS18, which has bee ...
Excessive interfacial micromotion endangers the implant primary stability by favoring the formation of a fibrous tissue layer at the bone-implant interface. It was recently proposed that implant micromotion induces fluid flow in the granulation tissue that ...
In attempts to elucidate the underlying mechanisms of spinal injuries and spinal deformities, several experimental and numerical studies have been conducted to understand the biomechanical behavior of the spine. However, numerical biomechanical studies suf ...
Bone defects generate a worldwide high demand for bone repair and reconstruction. The incidence of bone defect repair in our aging society is expected to increase in the next decades. As bone auto- and allografting solutions often suffer from limited suppl ...
We describe the bifurcation diagrams of almost toric integrable Hamiltonian systems on a four dimensional symplectic manifold M, not necessarily compact. We prove that, under a weak assumption, the connectivity of the fibers of the induced singular Lagrang ...
Device for testing a material response, such as a tissue response, to a compound; said device comprising material impedance measuring means which are adapted to measure the material impedance at the compound action site. ...
Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials correspo ...
Functional and structural connectivity convey different information about the brain. The integration of these different approaches is receiving growing attention from the research community, as it can shed new light on brain functions. This manuscript prop ...
Decellularized extracellular matrix (ECM) derived scaffolds serve as potential candidates in the application of cartilage regeneration to guide cells into proliferating and maintaining the structural zones of articular cartilage. ECM tissue matrices offer fr ...