Publications related to DNA database

Neural ADMIXTURE for rapid genomic clustering

Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...

SPRINGERNATURE2023

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Jacques Fellay, Christian Axel Wandall Thorball, Shuting Xu

Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3-driven antiviral responses. In this study, we characterized the ability of a specific ...

AMER ASSOC IMMUNOLOGISTS2022

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Didier Trono, Julien Paul André Pontis, Yu Tao

The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...

NATURE PORTFOLIO2022

A platform for experimental precision medicine: The extended BXD mouse family

Johan Auwerx, Evan Graehl Williams

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...

CELL PRESS2021

2D MoS2 nanopores: ionic current blockade height for clustering DNA events

Aleksandra Radenovic, Ke Liu

2D nanopores can be used to electrophoretically drive DNA molecules, which can in turn be identified through measurable electronic current blockades. In this work, we use experimental data from molybdenum disulfide nanopores threading DNA nucleotides and p ...

IOP PUBLISHING LTD2019

PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix

Giovanna Ambrosini, Philipp Bucher, Romain Fernand Pietro Groux

Transcription factors (TFs) regulate gene expression by binding to specific short DNA sequences of 5 to 20-bp to regulate the rate of transcription of genetic information from DNA to messenger RNA. We present PWMScan, a fast web-based tool to scan server-r ...

2018

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Beat Fierz, Andreas Linus Bachmann

Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27 to mark genes for repression. We measured the dynamics of PRC2 binding on recombinant chromatin and free DNA at the single-molecule level using total internal reflection fluorescenc ...

Nature Publishing Group2017

Contribution of R-UHPFRC Strengthening Layers to the Shear Resistance of RC Elements

Eugen Brühwiler, Maléna Bastien Masse

To strengthen a reinforced concrete (RC) slab with deficient shear resistance, it is proposed to add to the top of the slab a 25-50 mm thick layer of ultra-high performance fibre reinforced cement-based composite (UHPFRC) with small diameter rebars (R-UHPF ...

Iabse2016

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DNA database

Neural ADMIXTURE for rapid genomic clustering

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction

A platform for experimental precision medicine: The extended BXD mouse family

2D MoS2 nanopores: ionic current blockade height for clustering DNA events

PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Contribution of R-UHPFRC Strengthening Layers to the Shear Resistance of RC Elements

Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma

Graph Chatbot

Chat with Graph Search

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

2D MoS2 nanopores: ionic current blockade height for clustering DNA events

Neural ADMIXTURE for rapid genomic clustering

Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma

A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913

PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction

PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix

A platform for experimental precision medicine: The extended BXD mouse family

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

Contribution of R-UHPFRC Strengthening Layers to the Shear Resistance of RC Elements