Concept

Electrophilic addition

Related publications (27)

Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation

Yimon Aye, Pierre Alexander Miranda Herrera

ABSTRACT: Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophile ...

AMER CHEMICAL SOC2022

Umpolung Of Electron-Rich Heteroarenes With Hypervalent Iodine Reagents

Jérôme Waser, Raj Kumar Nandi

Five-membered heterocycles are well known for their innate nucleophilicity. In contrast, reaction of these heterocycles as electrophiles is less established and has become only recently an intensively investigated research area in synthetic chemistry. The ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Reactions of nitrogen-containing compounds with ozone: kinetics and mechanisms

Sung Eun Lim

Nitrogen-containing moieties are widespread in natural waters in dissolved organic nitrogen and micropollu-tants. They are often susceptible to an electrophilic attack of ozone because of the electron-rich nature of the neutral form of nitrogen in organic ...

EPFL2020

Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway

Kristin Schirmer, Alena Tierbach

Zebrafish (Danio rerio) early life stages offer a versatile model system to study the efficacy and safety of drugs or other chemicals with regard to human and environmental health. This is because, aside from the well-characterized genome of zebrafish and ...

OXFORD UNIV PRESS2020

Role of glutathione S-transferases and the mercapturic acid pathway in the biotransformation potential of two zebrafish (Danio rerio) test systems: early life stages and PAC2 cells

Alena Tierbach

Zebrafish (Danio rerio) early life stages provide an important model for chemical risk assessment due to their genetic similarity to humans and the availability of well-established high-throughput techniques. Cells isolated from zebrafish conserve all thes ...

EPFL2020

Shape and size control of colloidal CdSe nanocrystals in the presence of carboxylate and alkylamine ligands

Xiaopeng Huang

In this thesis, we focus on investigating the shape and size evolution of colloidal CdSe nanomaterials in the presence of carboxylate and alkylamine surface ligands. By elaborating the combination of carboxylates and alkylamines with different hydrocarbon ...

EPFL2019

Mechanistic Aspects of the Formation of Adsorbable Organic Bromine during Chlorination of Bromide-containing Synthetic Waters

Urs von Gunten

During chlorination of bromide-containing waters, a significant formation of brominated disinfection byproducts is expected. This is of concern because Br-DBPs are generally more toxic than their chlorinated analogues. In this study, synthetic water sample ...

Amer Chemical Soc2017

Stereoselective synthesis of alkenes via base-metal-catalyzed addition reactions to alkynes and activation of hydrogen peroxide and carbon dioxide by iron complexes

Fedor Zhurkin

Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...

EPFL2017

Regioselective Nitration and/or Halogenation of Iridabenzofurans through Electrophilic Substitution

Andrew Francis Dalebrook

Regioselective electrophilic substitution reactions of the iridabenzofurans [Ir(C7H5O{OMe-7})(CO)(PPh3)(2)]-[OTf] (1) and IrCl(C7H5O{OMe-7})(PPh3)(2) (2) provide a convenient route to mononitro-, dinitro-, and mixed nitro-/halo- substituted derivatives. Tr ...

Amer Chemical Soc2016

Synthesis of Alkynylated Heterocycles by Direct C-H Alkynylation or Domino Alkynylation Reactions

Yifan Li

Heterocycles are important compounds in organic chemistry. To introduce functional groups on heterocycles or synthesize functionalized heterocycles stays a hot topic of research. Among all the functional groups, alkynes attracted a lot of attention not onl ...

EPFL2016

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