Concept

Signal transducing adaptor protein

Related publications (36)

Patterning signals acting in the spinal cord override the organizing activity of the isthmus

The regionalization of the neural tube along the anteroposterior axis is established through the action of patterning signals from the endo-mesoderm including the organizer. These signals set up a pre-pattern which is subsequently refined through local pat ...

1999

The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions

Didier Trono

Human immunodeficiency virus Nef plays an important role in AIDS pathogenesis. In addition to the well known down-regulation of cell surface receptors (CD4, MHCI), Nef is able to alter cellular signaling. Of particular interest for this study is the abilit ...

1999

The Nef protein of primate lentiviruses

Didier Trono

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may accelerat ...

1999

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

Didier Trono

The Nef protein of primate lentiviruses down-regulates the cell surface expression of CD4 and probably MHC I by connecting these receptors with the endocytic machinery. Here, we reveal that Nef interacts with the mu chains of adaptor complexes, key compone ...

1998

Involvement of second messengers in regulation of the low-density lipoprotein receptor gene

Johan Auwerx

Transcription of the low-density lipoprotein receptor (LDL-R) gene in the human monocytic leukemic cell line THP-1 and in the human hepatocarcinoma cell line Hep-G2 is regulated by second messengers of the diacylglycerol-protein kinase C (DAG-PKC), inosito ...

1989

Molecular characterisation of the colicin E2 operon and identification of its products

Stewart Cole

The DNA sequence of the entire colicin E2 operon was determined. The operon comprises the colicin activity gene, ceaB, the colicin immunity gene, ceiB, and the lysis gene, celB, which is essential for colicin release from producing cells. A potential LexA ...

1985

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